Degradation of cells dying by apoptosis leads to accumulation of ε(γ-glutamyl)lysine isodipeptide in culture fluid and blood

L. Fésüs, Edit Tarcsa, Noemi Kedei, Francesco Autuori, Mauro Piacentini

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

ε(γ-Glutamyl)lysine isodipeptide, the end-product of proteolytic digestion of proteins cross-linked by transglutaminase, was detected in culture fluid of neonatal rat hepatocytes and plasma of adult rats. The concentration of the isodipeptide was significantly increased in both when high rate of apoptosis with phagocytosis of dying hepatocytes was produced either by epidermal growth factor in the culture or by lead nitrate-induced hyperplasia with subsequent involution in rats. Specific induction of tissue transglutaminase and the consequent formation of highly cross-linked protein envelopes in apoptotic cells have been previously demonstrated by us in both systems.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalFEBS Letters
Volume284
Issue number1
DOIs
Publication statusPublished - Jun 17 1991

Fingerprint

Lysine
Rats
Blood
Apoptosis
Degradation
Fluids
Hepatocytes
Transglutaminases
Phagocytosis
Epidermal Growth Factor
Proteolysis
Hyperplasia
Proteins
Cells
Plasmas
lead nitrate
transglutaminase 2

Keywords

  • Apoptosis
  • Hepatocyte
  • Isodipeptide
  • Phagocytosis
  • Transglutaminase
  • ε(γ-glutamyl)lysine

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Degradation of cells dying by apoptosis leads to accumulation of ε(γ-glutamyl)lysine isodipeptide in culture fluid and blood. / Fésüs, L.; Tarcsa, Edit; Kedei, Noemi; Autuori, Francesco; Piacentini, Mauro.

In: FEBS Letters, Vol. 284, No. 1, 17.06.1991, p. 109-112.

Research output: Contribution to journalArticle

Fésüs, L. ; Tarcsa, Edit ; Kedei, Noemi ; Autuori, Francesco ; Piacentini, Mauro. / Degradation of cells dying by apoptosis leads to accumulation of ε(γ-glutamyl)lysine isodipeptide in culture fluid and blood. In: FEBS Letters. 1991 ; Vol. 284, No. 1. pp. 109-112.
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