Definition and diagnostic criteria of sleep-related hypermotor epilepsy

Paolo Tinuper, Francesca Bisulli, J. H. Cross, Dale Hesdorffer, Philippe Kahane, Lino Nobili, Federica Provini, Ingrid E. Scheffer, Laura Tassi, Luca Vignatelli, Claudio Bassetti, Fabio Cirignotta, Christopher Derry, Antonio Gambardella, Renzo Guerrini, P. Halász, Laura Licchetta, Mark Mahowald, Raffaele Manni, Carla Marini & 10 others Barbara Mostacci, Ilaria Naldi, Liborio Parrino, Fabienne Picard, Maura Pugliatti, Philippe Ryvlin, Federico Vigevano, Marco Zucconi, Samuel Berkovic, Ruth Ottman

Research output: Contribution to journalReview article

70 Citations (Scopus)

Abstract

The syndrome known as nocturnal frontal lobe epilepsy is recognized worldwide and has been studied in a wide range of clinical and scientific settings (epilepsy, sleep medicine, neurosurgery, pediatric neurology, epidemiology, genetics). Though uncommon, it is of considerable interest to practicing neurologists because of complexity in differential diagnosis from more common, benign sleep disorders such as parasomnias, or other disorders like psychogenic nonepileptic seizures.Moreover, misdiagnosis can have substantial adverse consequences on patients' lives. At present, there is no consensus definition of this disorder and disagreement persists about its core electroclinical features and the spectrum of etiologies involved. To improve the definition of the disorder and establish diagnostic criteria with levels of certainty, a consensus conference using formal recommended methodology was held in Bologna in September 2014. It was recommended that the name be changed to sleep-related hypermotor epilepsy (SHE), reflecting evidence that the attacks are associated with sleep rather than time of day, the seizures may arise from extrafrontal sites, and the motor aspects of the seizures are characteristic. The etiology may be genetic or due to structural pathology, but in most cases remains unknown. Diagnostic criteria were developed with 3 levels of certainty: witnessed (possible) SHE, video-documented (clinical) SHE, and video-EEG-documented (confirmed) SHE. Themain research gaps involve epidemiology, pathophysiology, treatment, and prognosis.

Original languageEnglish
Pages (from-to)1834-1842
Number of pages9
JournalNeurology
Volume86
Issue number19
DOIs
Publication statusPublished - May 10 2016

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Epilepsy
Sleep
Seizures
Frontal Lobe Epilepsy
Parasomnias
Molecular Epidemiology
Neurosurgery
Neurology
Diagnostic Errors
Names
Electroencephalography
Consensus
Epidemiology
Differential Diagnosis
Medicine
Pediatrics
Pathology
Research
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Tinuper, P., Bisulli, F., Cross, J. H., Hesdorffer, D., Kahane, P., Nobili, L., ... Ottman, R. (2016). Definition and diagnostic criteria of sleep-related hypermotor epilepsy. Neurology, 86(19), 1834-1842. https://doi.org/10.1212/WNL.0000000000002666

Definition and diagnostic criteria of sleep-related hypermotor epilepsy. / Tinuper, Paolo; Bisulli, Francesca; Cross, J. H.; Hesdorffer, Dale; Kahane, Philippe; Nobili, Lino; Provini, Federica; Scheffer, Ingrid E.; Tassi, Laura; Vignatelli, Luca; Bassetti, Claudio; Cirignotta, Fabio; Derry, Christopher; Gambardella, Antonio; Guerrini, Renzo; Halász, P.; Licchetta, Laura; Mahowald, Mark; Manni, Raffaele; Marini, Carla; Mostacci, Barbara; Naldi, Ilaria; Parrino, Liborio; Picard, Fabienne; Pugliatti, Maura; Ryvlin, Philippe; Vigevano, Federico; Zucconi, Marco; Berkovic, Samuel; Ottman, Ruth.

In: Neurology, Vol. 86, No. 19, 10.05.2016, p. 1834-1842.

Research output: Contribution to journalReview article

Tinuper, P, Bisulli, F, Cross, JH, Hesdorffer, D, Kahane, P, Nobili, L, Provini, F, Scheffer, IE, Tassi, L, Vignatelli, L, Bassetti, C, Cirignotta, F, Derry, C, Gambardella, A, Guerrini, R, Halász, P, Licchetta, L, Mahowald, M, Manni, R, Marini, C, Mostacci, B, Naldi, I, Parrino, L, Picard, F, Pugliatti, M, Ryvlin, P, Vigevano, F, Zucconi, M, Berkovic, S & Ottman, R 2016, 'Definition and diagnostic criteria of sleep-related hypermotor epilepsy', Neurology, vol. 86, no. 19, pp. 1834-1842. https://doi.org/10.1212/WNL.0000000000002666
Tinuper P, Bisulli F, Cross JH, Hesdorffer D, Kahane P, Nobili L et al. Definition and diagnostic criteria of sleep-related hypermotor epilepsy. Neurology. 2016 May 10;86(19):1834-1842. https://doi.org/10.1212/WNL.0000000000002666
Tinuper, Paolo ; Bisulli, Francesca ; Cross, J. H. ; Hesdorffer, Dale ; Kahane, Philippe ; Nobili, Lino ; Provini, Federica ; Scheffer, Ingrid E. ; Tassi, Laura ; Vignatelli, Luca ; Bassetti, Claudio ; Cirignotta, Fabio ; Derry, Christopher ; Gambardella, Antonio ; Guerrini, Renzo ; Halász, P. ; Licchetta, Laura ; Mahowald, Mark ; Manni, Raffaele ; Marini, Carla ; Mostacci, Barbara ; Naldi, Ilaria ; Parrino, Liborio ; Picard, Fabienne ; Pugliatti, Maura ; Ryvlin, Philippe ; Vigevano, Federico ; Zucconi, Marco ; Berkovic, Samuel ; Ottman, Ruth. / Definition and diagnostic criteria of sleep-related hypermotor epilepsy. In: Neurology. 2016 ; Vol. 86, No. 19. pp. 1834-1842.
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