Deficient leucocyte antisedimentation is related to post-stroke infections and outcome

T. Molnar, A. Peterfalvi, L. Szereday, G. Pusch, L. Szapáry, S. Komoly, L. Bogár, Z. Illies

Research output: Contribution to journalArticle

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Abstract

Background: Patients with stroke are more susceptible to infections, suggesting possible deficiencies of early immune responses, particularly of leucocytes. Aims: To serially examine leucocyte antisedimentation rate (LAR), a simple test to detect activation of leucocytes, and correlate it with S100β, procalcitonin and outcome in patients with acute ischaemic events. Methods: Venous blood samples were taken from 61 healthy volunteers and 49 patients with acute ischaemic events (acute ischaemic stroke (AIS), n = 38; transient ischaemic attack (TIA), n = 11) within 6 hours, at 24 and 72 hours after onset of symptoms. Results: LAR was significantly higher in acute ischaemic events compared to controls within 6 hours after onset of stroke regardless of post-stroke infections. In addition, the increase of LAR was delayed and attenuated in TIA in contrast to AIS. A deficiency in early increase of LAR was associated with post-stroke infections and a poor outcome, measured by the Glasgow Outcome Scale in AIS. There was a positive correlation between LAR and S100β at 72 hours after the onset of ischaemic stroke. Increased levels of S100β at 24 and 72 hours after stroke were associated with poor outcome. Conclusions: An early activation of leucocytes indicated by an increase of LAR is characteristic of acute ischaemic cerebrovascular events. A delayed and ameliorated leucocyte activation represented by LAR is characteristic of TIA in contrast to stroke. Deficient early activation predisposes to post-stroke infections related to poor outcome. In addition, the extent of tissue injury correlates with the magnitude of innate immune responses.

Original languageEnglish
Pages (from-to)1209-1213
Number of pages5
JournalJournal of Clinical Pathology
Volume61
Issue number11
DOIs
Publication statusPublished - 2008

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Leukocytes
Stroke
Infection
Transient Ischemic Attack
Glasgow Outcome Scale
Calcitonin
Innate Immunity
Healthy Volunteers
Wounds and Injuries

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

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Deficient leucocyte antisedimentation is related to post-stroke infections and outcome. / Molnar, T.; Peterfalvi, A.; Szereday, L.; Pusch, G.; Szapáry, L.; Komoly, S.; Bogár, L.; Illies, Z.

In: Journal of Clinical Pathology, Vol. 61, No. 11, 2008, p. 1209-1213.

Research output: Contribution to journalArticle

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abstract = "Background: Patients with stroke are more susceptible to infections, suggesting possible deficiencies of early immune responses, particularly of leucocytes. Aims: To serially examine leucocyte antisedimentation rate (LAR), a simple test to detect activation of leucocytes, and correlate it with S100β, procalcitonin and outcome in patients with acute ischaemic events. Methods: Venous blood samples were taken from 61 healthy volunteers and 49 patients with acute ischaemic events (acute ischaemic stroke (AIS), n = 38; transient ischaemic attack (TIA), n = 11) within 6 hours, at 24 and 72 hours after onset of symptoms. Results: LAR was significantly higher in acute ischaemic events compared to controls within 6 hours after onset of stroke regardless of post-stroke infections. In addition, the increase of LAR was delayed and attenuated in TIA in contrast to AIS. A deficiency in early increase of LAR was associated with post-stroke infections and a poor outcome, measured by the Glasgow Outcome Scale in AIS. There was a positive correlation between LAR and S100β at 72 hours after the onset of ischaemic stroke. Increased levels of S100β at 24 and 72 hours after stroke were associated with poor outcome. Conclusions: An early activation of leucocytes indicated by an increase of LAR is characteristic of acute ischaemic cerebrovascular events. A delayed and ameliorated leucocyte activation represented by LAR is characteristic of TIA in contrast to stroke. Deficient early activation predisposes to post-stroke infections related to poor outcome. In addition, the extent of tissue injury correlates with the magnitude of innate immune responses.",
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T1 - Deficient leucocyte antisedimentation is related to post-stroke infections and outcome

AU - Molnar, T.

AU - Peterfalvi, A.

AU - Szereday, L.

AU - Pusch, G.

AU - Szapáry, L.

AU - Komoly, S.

AU - Bogár, L.

AU - Illies, Z.

PY - 2008

Y1 - 2008

N2 - Background: Patients with stroke are more susceptible to infections, suggesting possible deficiencies of early immune responses, particularly of leucocytes. Aims: To serially examine leucocyte antisedimentation rate (LAR), a simple test to detect activation of leucocytes, and correlate it with S100β, procalcitonin and outcome in patients with acute ischaemic events. Methods: Venous blood samples were taken from 61 healthy volunteers and 49 patients with acute ischaemic events (acute ischaemic stroke (AIS), n = 38; transient ischaemic attack (TIA), n = 11) within 6 hours, at 24 and 72 hours after onset of symptoms. Results: LAR was significantly higher in acute ischaemic events compared to controls within 6 hours after onset of stroke regardless of post-stroke infections. In addition, the increase of LAR was delayed and attenuated in TIA in contrast to AIS. A deficiency in early increase of LAR was associated with post-stroke infections and a poor outcome, measured by the Glasgow Outcome Scale in AIS. There was a positive correlation between LAR and S100β at 72 hours after the onset of ischaemic stroke. Increased levels of S100β at 24 and 72 hours after stroke were associated with poor outcome. Conclusions: An early activation of leucocytes indicated by an increase of LAR is characteristic of acute ischaemic cerebrovascular events. A delayed and ameliorated leucocyte activation represented by LAR is characteristic of TIA in contrast to stroke. Deficient early activation predisposes to post-stroke infections related to poor outcome. In addition, the extent of tissue injury correlates with the magnitude of innate immune responses.

AB - Background: Patients with stroke are more susceptible to infections, suggesting possible deficiencies of early immune responses, particularly of leucocytes. Aims: To serially examine leucocyte antisedimentation rate (LAR), a simple test to detect activation of leucocytes, and correlate it with S100β, procalcitonin and outcome in patients with acute ischaemic events. Methods: Venous blood samples were taken from 61 healthy volunteers and 49 patients with acute ischaemic events (acute ischaemic stroke (AIS), n = 38; transient ischaemic attack (TIA), n = 11) within 6 hours, at 24 and 72 hours after onset of symptoms. Results: LAR was significantly higher in acute ischaemic events compared to controls within 6 hours after onset of stroke regardless of post-stroke infections. In addition, the increase of LAR was delayed and attenuated in TIA in contrast to AIS. A deficiency in early increase of LAR was associated with post-stroke infections and a poor outcome, measured by the Glasgow Outcome Scale in AIS. There was a positive correlation between LAR and S100β at 72 hours after the onset of ischaemic stroke. Increased levels of S100β at 24 and 72 hours after stroke were associated with poor outcome. Conclusions: An early activation of leucocytes indicated by an increase of LAR is characteristic of acute ischaemic cerebrovascular events. A delayed and ameliorated leucocyte activation represented by LAR is characteristic of TIA in contrast to stroke. Deficient early activation predisposes to post-stroke infections related to poor outcome. In addition, the extent of tissue injury correlates with the magnitude of innate immune responses.

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