Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep

Mehdi Tafti, Brice Petit, Didier Chollet, Elisabeth Neidhart, Fabienne De Bilbao, J. Kiss, Philip A. Wood, Paul Franken

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

In rodents, the electroencephalogram (EEG) during paradoxical sleep and exploratory behavior is characterized by theta oscillations. Here we show that a deficiency in short-chain acylcoenzyme A dehydrogenase (encoded by Acads) in mice causes a marked slowing in theta frequency during paradoxical sleep only. We found Acads expression in brain regions involved in theta generation, notably the hippocampus. Microarray analysis of gene expression in mice with mutations in Acads indicates overexpression of Glo1 (encoding glyoxylase 1), a gene involved in the detoxification of metabolic by-products. Administration of acetyl-L-carnitine (ALCAR) to mutant mice significantly recovers slow theta and Glo1 overexpression. Thus, an underappreciated metabolic pathway involving fatty acid β-oxidation also regulates theta oscillations during sleep.

Original languageEnglish
Pages (from-to)320-325
Number of pages6
JournalNature Genetics
Volume34
Issue number3
DOIs
Publication statusPublished - Jul 1 2003

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Volatile Fatty Acids
Sleep
REM Sleep
Acetylcarnitine
Exploratory Behavior
Microarray Analysis
Metabolic Networks and Pathways
Electroencephalography
Rodentia
Hippocampus
Oxidoreductases
Fatty Acids
Gene Expression
Mutation
Brain
Genes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Tafti, M., Petit, B., Chollet, D., Neidhart, E., De Bilbao, F., Kiss, J., ... Franken, P. (2003). Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep. Nature Genetics, 34(3), 320-325. https://doi.org/10.1038/ng1174

Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep. / Tafti, Mehdi; Petit, Brice; Chollet, Didier; Neidhart, Elisabeth; De Bilbao, Fabienne; Kiss, J.; Wood, Philip A.; Franken, Paul.

In: Nature Genetics, Vol. 34, No. 3, 01.07.2003, p. 320-325.

Research output: Contribution to journalArticle

Tafti, M, Petit, B, Chollet, D, Neidhart, E, De Bilbao, F, Kiss, J, Wood, PA & Franken, P 2003, 'Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep', Nature Genetics, vol. 34, no. 3, pp. 320-325. https://doi.org/10.1038/ng1174
Tafti, Mehdi ; Petit, Brice ; Chollet, Didier ; Neidhart, Elisabeth ; De Bilbao, Fabienne ; Kiss, J. ; Wood, Philip A. ; Franken, Paul. / Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep. In: Nature Genetics. 2003 ; Vol. 34, No. 3. pp. 320-325.
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