Deferoxamine, the newly developed iron chelator LK-614 and N-α-acetyl-histidine in myocardial protection

Achim Koch, Sivakkanan Loganathan, T. Radovits, Falk Udo Sack, Matthias Karck, G. Szabó

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

During cold storage of donor hearts, reactive oxygen species produced by intracellular redox-active chelatable iron potentially alter myocardial function. To reduce this cold-induced injury we investigated the efficacy of two new modifications of the well established histidine-tryptophan-ketogluterate (HTK) solution (Custodiol®) with the addition of N-α-acetyl-L- histidine and iron-chelators in a heterotopic rat heart transplantation model. The donor hearts were cardioplegically arrested with 20 ml cardioplegia and stored for 1 h. Then the hearts were anastomosed to the abdominal aorta and vena cava of the recipient (n=30). After 1 h reperfusion, myocardial function and energy charge potential were measured in three groups: HTK-1: addition of L-arginine and N-α-acetyl-L-histidine; HTK-2: addition of iron-chelators deferoxamine and LK-614; traditional HTK - control. After 1 h reperfusion, left ventricular systolic pressure (106±33 vs. 60±39, vs. 67±8 mmHg, P

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalInteractive Cardiovascular and Thoracic Surgery
Volume10
Issue number2
DOIs
Publication statusPublished - 2010

Fingerprint

Deferoxamine
Chelating Agents
Histidine
Iron
Tryptophan
Reperfusion
Induced Heart Arrest
Venae Cavae
Abdominal Aorta
Ventricular Pressure
Heart Transplantation
Oxidation-Reduction
Reactive Oxygen Species
Blood Pressure

Keywords

  • Cold ischemic injury
  • Iron chelators
  • N-α-acetyl-L-histidine
  • Rat heart transplantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Deferoxamine, the newly developed iron chelator LK-614 and N-α-acetyl-histidine in myocardial protection. / Koch, Achim; Loganathan, Sivakkanan; Radovits, T.; Sack, Falk Udo; Karck, Matthias; Szabó, G.

In: Interactive Cardiovascular and Thoracic Surgery, Vol. 10, No. 2, 2010, p. 181-184.

Research output: Contribution to journalArticle

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