Defective production of interleukin-1 and tumour necrosis factor-alpha by stimulated monocytes from patients with systemic lupus erythematosus.

G. Mũzes, C. V. Vien, R. González-Cabello, J. Fehér, P. Gergely

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Interleukin-1 and tumour necrosis factor-alpha activity by E. coli lipopolysaccharide-triggered monocytes was studied in patients with systemic lupus erythematosus in various stages of activity. Monocytes from both groups of SLE patients produced significantly less tumour necrosis factor-alpha activity than those of age and sex matched healthy controls. However, interleukin-1 activity was only significantly reduced in patients with active stage of the disease. These findings indicate further immunoregulatory disturbances in monocyte function concerning SLE.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalActa medica Hungarica
Volume46
Issue number4
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Defective production of interleukin-1 and tumour necrosis factor-alpha by stimulated monocytes from patients with systemic lupus erythematosus.'. Together they form a unique fingerprint.

  • Cite this