Defective monocyte chemotaxis in systemic lupus erythematosus

K. Lukacs, M. Kavai, S. Sipka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Monocyte chemotaxis and lymphokine activity of patients with systemic lupus erythematosus (SLE) were studied with the leading front method using disposable chemotactic chambers. Although spontaneous migration was unimpaired, chemotaxis of the patients significantly decreased. Both the sera and the isolated immune complex (IC) of SLE patients showed inhibited monocyte chemotaxis and the inhibition was uninfluenced by heat. At the same time the chemotactic activity of lymphokines, produced by the Con-A stimulated lymphocytes from patients, did not differ significantly from that of the lymphokines of healthy donors. It is suggested that the development and persistence of the illness depend on the monocyte dysfunction in SLE rather than on the defective lymphokine production.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalActa Medica Academiae Scientiarum Hungaricae
Volume38
Issue number1
Publication statusPublished - 1981

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Lymphokines
Chemotaxis
Systemic Lupus Erythematosus
Monocytes
Cell Migration Inhibition
Antigen-Antibody Complex
Hot Temperature
Tissue Donors
Lymphocytes
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Defective monocyte chemotaxis in systemic lupus erythematosus. / Lukacs, K.; Kavai, M.; Sipka, S.

In: Acta Medica Academiae Scientiarum Hungaricae, Vol. 38, No. 1, 1981, p. 49-55.

Research output: Contribution to journalArticle

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