Decreased serum and red blood cell kynurenic acid levels in Alzheimer's disease

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Abstract

Kynurenine aminotransferases (KAT I and KAT II) are responsible for the transamination of kynurenine (KYN) to form kynurenic acid (KYNA), an excitatory amino acid receptor antagonist. Since these members of the kynurenine pathway (KP) are proposed to be involved in the pathogenesis of Alzheimer's dementia (AD), the activities of these enzymes and the levels of these metabolites were measured in the plasma and red blood cells (RBCs) of AD and control subjects together with the inheritance of the apolipoprotein (APOE) ε4 allele. KYNA levels were significantly decreased both in the plasma and in the RBCs in AD, but the levels of KYN and the activities of KAT I and KAT II remained unchanged. No association has been found with the possession of the ε4 allele. These findings indicate an altered peripheral KP in AD regardless of the APOE status of the probands.

Original languageEnglish
Pages (from-to)308-313
Number of pages6
JournalNeurochemistry International
Volume50
Issue number2
DOIs
Publication statusPublished - Jan 2007

Fingerprint

Kynurenic Acid
Kynurenine
Alzheimer Disease
Erythrocytes
Apolipoproteins
kynurenine-oxoglutarate transaminase
Serum
Alleles
Excitatory Amino Acid Antagonists
Glutamate Receptors
Enzymes

Keywords

  • Alzheimer's dementia
  • Apolipoprotein E
  • Kynurenic acid
  • Kynurenine aminotransferase
  • Kynurenine pathway

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

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title = "Decreased serum and red blood cell kynurenic acid levels in Alzheimer's disease",
abstract = "Kynurenine aminotransferases (KAT I and KAT II) are responsible for the transamination of kynurenine (KYN) to form kynurenic acid (KYNA), an excitatory amino acid receptor antagonist. Since these members of the kynurenine pathway (KP) are proposed to be involved in the pathogenesis of Alzheimer's dementia (AD), the activities of these enzymes and the levels of these metabolites were measured in the plasma and red blood cells (RBCs) of AD and control subjects together with the inheritance of the apolipoprotein (APOE) ε4 allele. KYNA levels were significantly decreased both in the plasma and in the RBCs in AD, but the levels of KYN and the activities of KAT I and KAT II remained unchanged. No association has been found with the possession of the ε4 allele. These findings indicate an altered peripheral KP in AD regardless of the APOE status of the probands.",
keywords = "Alzheimer's dementia, Apolipoprotein E, Kynurenic acid, Kynurenine aminotransferase, Kynurenine pathway",
author = "Zsuzsanna Hartai and A. Juh{\'a}sz and A. Riman{\'o}czy and T. Jan{\'a}ky and Teod{\'o}ra Donk{\'o} and L. Dux and B. Penke and G. T{\'o}th and Z. Janka and J. K{\'a}lm{\'a}n",
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T1 - Decreased serum and red blood cell kynurenic acid levels in Alzheimer's disease

AU - Hartai, Zsuzsanna

AU - Juhász, A.

AU - Rimanóczy, A.

AU - Janáky, T.

AU - Donkó, Teodóra

AU - Dux, L.

AU - Penke, B.

AU - Tóth, G.

AU - Janka, Z.

AU - Kálmán, J.

PY - 2007/1

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N2 - Kynurenine aminotransferases (KAT I and KAT II) are responsible for the transamination of kynurenine (KYN) to form kynurenic acid (KYNA), an excitatory amino acid receptor antagonist. Since these members of the kynurenine pathway (KP) are proposed to be involved in the pathogenesis of Alzheimer's dementia (AD), the activities of these enzymes and the levels of these metabolites were measured in the plasma and red blood cells (RBCs) of AD and control subjects together with the inheritance of the apolipoprotein (APOE) ε4 allele. KYNA levels were significantly decreased both in the plasma and in the RBCs in AD, but the levels of KYN and the activities of KAT I and KAT II remained unchanged. No association has been found with the possession of the ε4 allele. These findings indicate an altered peripheral KP in AD regardless of the APOE status of the probands.

AB - Kynurenine aminotransferases (KAT I and KAT II) are responsible for the transamination of kynurenine (KYN) to form kynurenic acid (KYNA), an excitatory amino acid receptor antagonist. Since these members of the kynurenine pathway (KP) are proposed to be involved in the pathogenesis of Alzheimer's dementia (AD), the activities of these enzymes and the levels of these metabolites were measured in the plasma and red blood cells (RBCs) of AD and control subjects together with the inheritance of the apolipoprotein (APOE) ε4 allele. KYNA levels were significantly decreased both in the plasma and in the RBCs in AD, but the levels of KYN and the activities of KAT I and KAT II remained unchanged. No association has been found with the possession of the ε4 allele. These findings indicate an altered peripheral KP in AD regardless of the APOE status of the probands.

KW - Alzheimer's dementia

KW - Apolipoprotein E

KW - Kynurenic acid

KW - Kynurenine aminotransferase

KW - Kynurenine pathway

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