Decreased sensory neuropeptide release in isolated bronchi of rats with cisplatin-induced neuropathy

Peter Horvath, Judith Szilvassy, J. Németh, Barna Peitl, Maria Szilasi, Z. Szilvássy

Research output: Contribution to journalArticle

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Abstract

We studied if attenuated neurogenic bronchoconstriction was associated with a change in sensory neuropeptide release in preparations from rats with cisplatin-induced neuropathy. Electrical field stimulation (100 stimuli, 20 V, 0.1 ms, 20 Hz) induced an increase in the release of somatostatin, calcitonin gene-related peptide (CGRP) and substance P determined by radioimmunoassay from baseline 0.18±0.01, 0.17±0.01 and 0.86±0.02, to 0.59±0.02, 1.77±0.04 and 5.96 fmol/mg wet tissue weight, respectively, in organ fluid of tracheal tubes from rats. This was significantly attenuated to post-stimulation values of 0.36±0.02, 0.45±0.02, 4.68±0.24 fmol/mg wet tissue weight for somatostatin, CGRP, and substance P, respectively, with a significant decrease in field stimulation-induced contraction of bronchial preparations from animals 11 days after a 5-day treatment period with cisplatin (1.5 mg/kg i.p. once a day). The cisplatin-treated animals developed sensory neuropathy characterized by a 40% decrease in femoral nerve conduction velocity. The results show that a decrease in tracheo-bronchial sensory neuropeptide release associates with feeble bronchomotor responses in rats with cisplatin-induced sensory neuropathy.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalEuropean Journal of Pharmacology
Volume507
Issue number1-3
DOIs
Publication statusPublished - Jan 10 2005

Fingerprint

Bronchi
Neuropeptides
Cisplatin
Calcitonin Gene-Related Peptide
Substance P
Somatostatin
Femoral Nerve
Weights and Measures
Bronchoconstriction
Neural Conduction
Electric Stimulation
Radioimmunoassay
peptide P

Keywords

  • Cisplatin
  • Neuropeptide release
  • Sensory neuropathy

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Decreased sensory neuropeptide release in isolated bronchi of rats with cisplatin-induced neuropathy. / Horvath, Peter; Szilvassy, Judith; Németh, J.; Peitl, Barna; Szilasi, Maria; Szilvássy, Z.

In: European Journal of Pharmacology, Vol. 507, No. 1-3, 10.01.2005, p. 247-252.

Research output: Contribution to journalArticle

Horvath, Peter ; Szilvassy, Judith ; Németh, J. ; Peitl, Barna ; Szilasi, Maria ; Szilvássy, Z. / Decreased sensory neuropeptide release in isolated bronchi of rats with cisplatin-induced neuropathy. In: European Journal of Pharmacology. 2005 ; Vol. 507, No. 1-3. pp. 247-252.
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