Decreased proportion of peripheral blood vascular endothelial growth factor-expressing T and natural killer cells in preeclampsia

A. Molvarec, Mika Ito, Tomoko Shima, Satoshi Yoneda, Gergely Toldi, Balázs Stenczer, B. Vásárhelyi, J. Rigó, Shigeru Saito

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: The purpose of this study was to determine the proportion of circulating T and natural killer (NK) cells that express intracellular vascular endothelial growth factor (VEGF) in women with preeclampsia compared to those with a normal pregnancy.STUDY DESIGN: In all, 24 preeclamptic patients and 30 healthy pregnant women were involved in this case-control study. Intracellular VEGF expression of unstimulated lymphocytes was determined with flow cytometric examination. RESULTS: In healthy pregnant women, the majority of both T and NK cells expressed VEGF in their cytoplasma (median, 79.9%; 25-75 percentile, 73.7-87.0 and median, 78.3%; 25-75 percentile, 64.1-85.3, respectively). Furthermore, CD4 + helper and CD8 + cytotoxic T cells showed a similar pattern of VEGF expression in normal pregnancy. However, the proportion of VEGF-expressing peripheral blood T (bothhelper and cytotoxic) and NK cells was markedly decreased in preeclampsia (for T cells: median, 51.6%; 25-75 percentile, 40.1-60.0; P <.001; for NK cells: median, 45.2%; 25-75 percentile, 27.4-64.0; P

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Volume203
Issue number6
DOIs
Publication statusPublished - Dec 2010

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Natural Killer T-Cells
Pre-Eclampsia
Vascular Endothelial Growth Factor A
Natural Killer Cells
Pregnant Women
T-Lymphocytes
Pregnancy
Case-Control Studies
Lymphocytes

Keywords

  • Inflammation
  • Lymphocyte
  • Preeclampsia
  • Pregnancy
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Decreased proportion of peripheral blood vascular endothelial growth factor-expressing T and natural killer cells in preeclampsia. / Molvarec, A.; Ito, Mika; Shima, Tomoko; Yoneda, Satoshi; Toldi, Gergely; Stenczer, Balázs; Vásárhelyi, B.; Rigó, J.; Saito, Shigeru.

In: American Journal of Obstetrics and Gynecology, Vol. 203, No. 6, 12.2010.

Research output: Contribution to journalArticle

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AU - Toldi, Gergely

AU - Stenczer, Balázs

AU - Vásárhelyi, B.

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