Decreased peroxisome proliferator-activated receptor γ level and signalling in sebaceous glands of patients with acne vulgaris

A. Dozsa, J. Mihaly, B. Dezső, E. Csizmadia, T. Keresztessy, L. Marko, R. Rühl, E. Remenyik, L. Nagy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Little is known about the altered lipid metabolism-related transcriptional events occuring in sebaceous glands of patients with acne vulgaris. Peroxisome proliferator-activated receptor (PPAR)γ, a lipid-activated transcription factor, is implicated in differentiation and lipid metabolism of sebocytes. We have observed that PPARγ and its target genes, ADRP (adipose differentiation related protein) and PGAR (PPARγ angioprotein related protein) are expressed at lower levels in sebocytes from patients with acne than in those from healthy controls (HCs) Furthermore, endogenous PPARγ activator lipids such as arachidonic acid-derived keto-metabolites (e.g. 5KETE, 12KETE) are increased in acne-involved and nonacne-involved skin of patients with acne, compared with skin from healthy individuals. Our findings highlight the possible anti-inflammatory role of endogenous ligand-activated PPARγ signaling in human sebocyte biology, and suggest that modulating PPARγ- expression and thereby signaling might be a promising strategy for the clinical management of acne vulgaris.

Original languageEnglish
Pages (from-to)547-551
Number of pages5
JournalClinical and Experimental Dermatology
Volume41
Issue number5
DOIs
Publication statusPublished - Jul 1 2016

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Sebaceous Glands
Peroxisome Proliferator-Activated Receptors
Acne Vulgaris
Lipid Metabolism
Lipids
Skin
Arachidonic Acid
Anti-Inflammatory Agents
Transcription Factors
Ligands
Genes
Proteins

ASJC Scopus subject areas

  • Dermatology

Cite this

Decreased peroxisome proliferator-activated receptor γ level and signalling in sebaceous glands of patients with acne vulgaris. / Dozsa, A.; Mihaly, J.; Dezső, B.; Csizmadia, E.; Keresztessy, T.; Marko, L.; Rühl, R.; Remenyik, E.; Nagy, L.

In: Clinical and Experimental Dermatology, Vol. 41, No. 5, 01.07.2016, p. 547-551.

Research output: Contribution to journalArticle

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AU - Csizmadia, E.

AU - Keresztessy, T.

AU - Marko, L.

AU - Rühl, R.

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