Decreased killer cell activity in preeclampsia

P. Siklós, Ágnes Németh-Csóka, Liliana Bartaliis, László Ungár, Péter Hercz, Klára Tótpál, Tamás Garam

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Anti-D antibody-dependent cellular cytotoxicity of peripheral blood mononu-clear cells was measured against O, Rh (D)-positive erythrocytes in 20 healthy pregnant women (chosen from all trimesters), and in 16 toxemic patients; it was then compared to the cytotoxic activities of 20 women 3 months after parturition and to that of 42 nonpregnant women. The application of an enzyme-like kinetic model for measurement of maximal cyto-toxic function has permitted sensitive determination of the K cell function. It was found that during normal pregnancy maternal K cell activity did not change, whereas it was significantly decreased in preeclampsia.

Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalGynecologic and Obstetric Investigation
Volume23
Issue number2
DOIs
Publication statusPublished - Jan 1 1987

Keywords

  • Antibody-dependent cellular cytotoxicity
  • Human erythrocytes
  • Killer cell activity
  • Normal and toxemic pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Decreased killer cell activity in preeclampsia'. Together they form a unique fingerprint.

  • Cite this

    Siklós, P., Németh-Csóka, Á., Bartaliis, L., Ungár, L., Hercz, P., Tótpál, K., & Garam, T. (1987). Decreased killer cell activity in preeclampsia. Gynecologic and Obstetric Investigation, 23(2), 84-88. https://doi.org/10.1159/000298840