Decreased killer cell activity in preeclampsia

P. Siklós, Ágnes Németh-Csóka, Liliana Bartaliis, L. Ungár, Péter Hercz, Klára Tótpál, Tamás Garam

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Anti-D antibody-dependent cellular cytotoxicity of peripheral blood mononu-clear cells was measured against O, Rh (D)-positive erythrocytes in 20 healthy pregnant women (chosen from all trimesters), and in 16 toxemic patients; it was then compared to the cytotoxic activities of 20 women 3 months after parturition and to that of 42 nonpregnant women. The application of an enzyme-like kinetic model for measurement of maximal cyto-toxic function has permitted sensitive determination of the K cell function. It was found that during normal pregnancy maternal K cell activity did not change, whereas it was significantly decreased in preeclampsia.

Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalGynecologic and Obstetric Investigation
Volume23
Issue number2
DOIs
Publication statusPublished - 1987

Fingerprint

Pre-Eclampsia
Poisons
Pregnant Women
Anti-Idiotypic Antibodies
Erythrocytes
Mothers
Parturition
Pregnancy
Enzymes

Keywords

  • Antibody-dependent cellular cytotoxicity
  • Human erythrocytes
  • Killer cell activity
  • Normal and toxemic pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Siklós, P., Németh-Csóka, Á., Bartaliis, L., Ungár, L., Hercz, P., Tótpál, K., & Garam, T. (1987). Decreased killer cell activity in preeclampsia. Gynecologic and Obstetric Investigation, 23(2), 84-88. https://doi.org/10.1159/000298840

Decreased killer cell activity in preeclampsia. / Siklós, P.; Németh-Csóka, Ágnes; Bartaliis, Liliana; Ungár, L.; Hercz, Péter; Tótpál, Klára; Garam, Tamás.

In: Gynecologic and Obstetric Investigation, Vol. 23, No. 2, 1987, p. 84-88.

Research output: Contribution to journalArticle

Siklós, P, Németh-Csóka, Á, Bartaliis, L, Ungár, L, Hercz, P, Tótpál, K & Garam, T 1987, 'Decreased killer cell activity in preeclampsia', Gynecologic and Obstetric Investigation, vol. 23, no. 2, pp. 84-88. https://doi.org/10.1159/000298840
Siklós P, Németh-Csóka Á, Bartaliis L, Ungár L, Hercz P, Tótpál K et al. Decreased killer cell activity in preeclampsia. Gynecologic and Obstetric Investigation. 1987;23(2):84-88. https://doi.org/10.1159/000298840
Siklós, P. ; Németh-Csóka, Ágnes ; Bartaliis, Liliana ; Ungár, L. ; Hercz, Péter ; Tótpál, Klára ; Garam, Tamás. / Decreased killer cell activity in preeclampsia. In: Gynecologic and Obstetric Investigation. 1987 ; Vol. 23, No. 2. pp. 84-88.
@article{65ab0226d5124415be39b180ef9c5bee,
title = "Decreased killer cell activity in preeclampsia",
abstract = "Anti-D antibody-dependent cellular cytotoxicity of peripheral blood mononu-clear cells was measured against O, Rh (D)-positive erythrocytes in 20 healthy pregnant women (chosen from all trimesters), and in 16 toxemic patients; it was then compared to the cytotoxic activities of 20 women 3 months after parturition and to that of 42 nonpregnant women. The application of an enzyme-like kinetic model for measurement of maximal cyto-toxic function has permitted sensitive determination of the K cell function. It was found that during normal pregnancy maternal K cell activity did not change, whereas it was significantly decreased in preeclampsia.",
keywords = "Antibody-dependent cellular cytotoxicity, Human erythrocytes, Killer cell activity, Normal and toxemic pregnancy",
author = "P. Sikl{\'o}s and {\'A}gnes N{\'e}meth-Cs{\'o}ka and Liliana Bartaliis and L. Ung{\'a}r and P{\'e}ter Hercz and Kl{\'a}ra T{\'o}tp{\'a}l and Tam{\'a}s Garam",
year = "1987",
doi = "10.1159/000298840",
language = "English",
volume = "23",
pages = "84--88",
journal = "Gynecologic and Obstetric Investigation",
issn = "0378-7346",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Decreased killer cell activity in preeclampsia

AU - Siklós, P.

AU - Németh-Csóka, Ágnes

AU - Bartaliis, Liliana

AU - Ungár, L.

AU - Hercz, Péter

AU - Tótpál, Klára

AU - Garam, Tamás

PY - 1987

Y1 - 1987

N2 - Anti-D antibody-dependent cellular cytotoxicity of peripheral blood mononu-clear cells was measured against O, Rh (D)-positive erythrocytes in 20 healthy pregnant women (chosen from all trimesters), and in 16 toxemic patients; it was then compared to the cytotoxic activities of 20 women 3 months after parturition and to that of 42 nonpregnant women. The application of an enzyme-like kinetic model for measurement of maximal cyto-toxic function has permitted sensitive determination of the K cell function. It was found that during normal pregnancy maternal K cell activity did not change, whereas it was significantly decreased in preeclampsia.

AB - Anti-D antibody-dependent cellular cytotoxicity of peripheral blood mononu-clear cells was measured against O, Rh (D)-positive erythrocytes in 20 healthy pregnant women (chosen from all trimesters), and in 16 toxemic patients; it was then compared to the cytotoxic activities of 20 women 3 months after parturition and to that of 42 nonpregnant women. The application of an enzyme-like kinetic model for measurement of maximal cyto-toxic function has permitted sensitive determination of the K cell function. It was found that during normal pregnancy maternal K cell activity did not change, whereas it was significantly decreased in preeclampsia.

KW - Antibody-dependent cellular cytotoxicity

KW - Human erythrocytes

KW - Killer cell activity

KW - Normal and toxemic pregnancy

UR - http://www.scopus.com/inward/record.url?scp=0023154293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023154293&partnerID=8YFLogxK

U2 - 10.1159/000298840

DO - 10.1159/000298840

M3 - Article

C2 - 3108085

AN - SCOPUS:0023154293

VL - 23

SP - 84

EP - 88

JO - Gynecologic and Obstetric Investigation

JF - Gynecologic and Obstetric Investigation

SN - 0378-7346

IS - 2

ER -