Decreased human paraoxonase-1 activity in patients with Sjögren's syndrome

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Abstract

Objectives: The aim of the study was to examine human serum paraoxonase 1 (PON1) activity, phenotype distribution and lipid parameters in patients with Sjögren's syndrome. The prevalence of cardio-and cerebrovascular diseases in SS patients was also evaluated after a 5-year follow-up. Methods. Fifty-seven SS patients and 17 age-matched healthy controls were enrolled into the study. PON1 and arylesterase activities were measured spectrophotometrically. The phenotype distribution of PON1 was determined by the dual-substrate method. Results. Significantly lower PON1 activity was found in patients with SS compared with the control group (98.00 6 69.21 versus 203.3 6 92.78 U ml-1; P < 0.001). There were significant differences in PON1 phenotype distribution of SS patients and controls (AA/AB/BB: 91.2/8.8/0 versus 58.8/29.4/11.8%; P < 0.01). No significant correlations were found between PON activity and disease-characteristic autoantibodies, including anti-Ro/SS-A and anti-La/SS-B concentrations. PON activity did not predict the cerebro/cardiovascular risk in SS patients during the 5-year follow-up. Conclusions: Despite the relatively small sample size that reduces the power of the study, decreased PON activity may be a possible cardiovascular risk factor in SS. Disadvantageous PON1 phenotype distribution may contribute to the decreased PON activity in these patients.

Original languageEnglish
Pages (from-to)605-609
Number of pages5
JournalInternational Immunology
Volume22
Issue number7
DOIs
Publication statusPublished - May 24 2010

Keywords

  • Autoimmunity
  • Cardiovascular risk
  • Paraoxonase phenotype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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