Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?

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Abstract

The relationship between CCl4 or (CCl4 + phenobarbital)-induced liver cirrhosis and diethylnitrosamine (DEN) hepatocarcinogenesis in male F-344 rats was investigated. DEN given alone produced no liver lesions after 16 weeks, but 4 12 (33%) neoplastic nodules developed when nitrosamine was administered to rats with previously established cirrhosis. On the other hand, (CCl4 + phenobarbital) post-treatment had an even stronger effect, increasing the yield of neoplastic nodules to 100% ( 28 28). Since the exposure time of DEN was the same in all treated groups (4 months), the results indicate the decreased effectiveness of (CCl4 + phenobarbital) pretreatment on DEN hepatocarcinogenesis.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalCancer Letters
Volume79
Issue number1
DOIs
Publication statusPublished - Apr 29 1994

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Keywords

  • Animal models
  • Carbon tetrachloride
  • Experimentally induced
  • Liver
  • Liver cirrhosis
  • Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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