Decreased heparin sensitivity of cyclohexanedione-modified Factor Xa

G. Blasko, R. Machovich

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Modification of 12 arginine residues of bovine Factor Xa with 1,2-cyclohexanedione has resulted in a decrease in heparin sensitivity of the reaction between enzyme and antithrombin-III, whereas the antithrombin-III sensitivity of modified Factor Xa was only slightly affected. It is suggested that heparin accelerates the Factor Xa-antithrombin-III reaction by interacting with Factor Xa.

Original languageEnglish
Pages (from-to)556-563
Number of pages8
JournalThrombosis and Haemostasis
Volume42
Issue number2
Publication statusPublished - 1979

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Factor Xa
Antithrombin III
Heparin
Arginine
Enzymes

ASJC Scopus subject areas

  • Hematology

Cite this

Decreased heparin sensitivity of cyclohexanedione-modified Factor Xa. / Blasko, G.; Machovich, R.

In: Thrombosis and Haemostasis, Vol. 42, No. 2, 1979, p. 556-563.

Research output: Contribution to journalArticle

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