Decreased expression of histamine H1 and H4 receptors suggests disturbance of local regulation in human colorectal tumours by histamine

Katalin Boer, Eva Helinger, Andrea Helinger, Peter Pocza, Z. Pós, P. Demeter, Zsolt Baranyai, Kristof Dede, Z. Darvas, A. Falus

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Production of histamine in colon tumours has been described earlier. Histamine-mediated signals have been shown to be implicated in tumour growth, and the effects of histamine are largely determined locally by the histamine receptor expression pattern. We analysed histamine receptor expression in human colorectal cancer, adenoma and normal mucosa by quantitative reverse transcription-polymerase chain reaction (RT-PCR), Western blot analysis and immunostaining. Real-time RT-PCR results revealed significantly decreased (p

Original languageEnglish
Pages (from-to)227-236
Number of pages10
JournalEuropean Journal of Cell Biology
Volume87
Issue number4
DOIs
Publication statusPublished - Apr 18 2008

Fingerprint

Histamine H1 Receptors
Histamine
Histamine Receptors
Colorectal Neoplasms
Reverse Transcription
Polymerase Chain Reaction
Adenoma
Neoplasms
Colon
Mucous Membrane
Western Blotting
Growth

Keywords

  • Colon adenoma
  • Colon mucosa
  • Colorectal tumour
  • Histamine
  • Histamine receptors

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Decreased expression of histamine H1 and H4 receptors suggests disturbance of local regulation in human colorectal tumours by histamine. / Boer, Katalin; Helinger, Eva; Helinger, Andrea; Pocza, Peter; Pós, Z.; Demeter, P.; Baranyai, Zsolt; Dede, Kristof; Darvas, Z.; Falus, A.

In: European Journal of Cell Biology, Vol. 87, No. 4, 18.04.2008, p. 227-236.

Research output: Contribution to journalArticle

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AU - Pocza, Peter

AU - Pós, Z.

AU - Demeter, P.

AU - Baranyai, Zsolt

AU - Dede, Kristof

AU - Darvas, Z.

AU - Falus, A.

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