Decreased circulating anandamide levels in preeclampsia

A. Molvarec, Gergely Fügedi, Eszter Szabó, Balázs Stenczer, Szilvia Walentin, J. Rigó

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The endocannabinoid system has a key role in female reproduction, including implantation, decidualization and placentation. A growing number of studies indicate that placental and peripheral blood anandamide levels correlate closely with both spontaneous miscarriage and ectopic pregnancy. Anandamide has also been implicated in blood pressure regulation. In this study, we aimed to determine circulating anandamide levels in preeclampsia for the first time in the literature. Forty-three preeclamptic patients and 71 healthy pregnant women were involved in this case-control study. Serum anandamide concentrations were determined by high-performance liquid chromatography-mass spectrometry technique. Serum total soluble fms-like tyrosine kinase-1 (sFlt-1) and biologically active placental growth factor (PlGF) levels were measured by electrochemiluminescence immunoassay. For statistical analyses, nonparametric methods were applied. Serum levels of anandamide were significantly lower in preeclamptic patients than in healthy pregnant women (0.75 (0.44-1.03) ng ml-1 vs. 1.30 (0.76-2.0) ng ml-1, P-1, P-1 vs. 256.8 (181.1-421.0) pg ml-1, P

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalHypertension Research
Volume38
Issue number6
DOIs
Publication statusPublished - Jun 8 2015

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Pre-Eclampsia
Pregnant Women
Serum
Vascular Endothelial Growth Factor Receptor-1
Placentation
Endocannabinoids
Ectopic Pregnancy
Spontaneous Abortion
Immunoassay
Reproduction
Case-Control Studies
Mass Spectrometry
Intercellular Signaling Peptides and Proteins
High Pressure Liquid Chromatography
anandamide
Blood Pressure

Keywords

  • anandamide
  • angiogenic factor
  • endocannabinoid
  • preeclampsia
  • pregnancy

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Decreased circulating anandamide levels in preeclampsia. / Molvarec, A.; Fügedi, Gergely; Szabó, Eszter; Stenczer, Balázs; Walentin, Szilvia; Rigó, J.

In: Hypertension Research, Vol. 38, No. 6, 08.06.2015, p. 413-418.

Research output: Contribution to journalArticle

Molvarec, A, Fügedi, G, Szabó, E, Stenczer, B, Walentin, S & Rigó, J 2015, 'Decreased circulating anandamide levels in preeclampsia', Hypertension Research, vol. 38, no. 6, pp. 413-418. https://doi.org/10.1038/hr.2015.20
Molvarec, A. ; Fügedi, Gergely ; Szabó, Eszter ; Stenczer, Balázs ; Walentin, Szilvia ; Rigó, J. / Decreased circulating anandamide levels in preeclampsia. In: Hypertension Research. 2015 ; Vol. 38, No. 6. pp. 413-418.
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