Decreased chemotaxis of human peripheral phagocytes exposed to a strong static magnetic field

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Abstract

The chemotaxis of human peripheral phagocytes, neutrophils and monocytes was examined in a strong static magnetic field (0.317±0.012 Tesla). The chemotaxis of the suspension of purified neutrophils and monocytes was tested in the Boyden chamber using C5a as a chemotactic signal. The chambers were placed into a temperature regulated (36.6 °C) equipment producing a strong static magnetic field (0.317 Tesla) for 60 minutes. The movement of cells proceeded into a nitrocellulose membrane toward the north-pole of the magnet, i.e. in the direction of the Earth's gravitational pull. The C5a induced chemotaxis of human neutrophils decreased significantly in the strong static magnetic field. Monocytes were not significantly effected. The strong static magnetic field decreased the chemotactic movement of neutrophils and this phenomenon may have implications when humans are exposed to magnetic resonance imaging for extended periods of time.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalActa physiologica Hungarica
Volume91
Issue number1
DOIs
Publication statusPublished - Jul 7 2004

Keywords

  • Chemotaxis
  • Monocytes
  • Neutrophils
  • Phagocytes
  • Strong static magnetic field

ASJC Scopus subject areas

  • Physiology (medical)

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