Decreased blood catalase activity is not related to specific beta-thalassemia mutations in Hungary

Z. Kósa, T. Nagy, E. Nagy, F. Fazakas, L. Góth

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Introduction: Thalassemia erythrocytes are exposed to oxidative stress especially to hydrogen peroxide, which is regulated with the enzyme catalase. The aim of this study was to examine blood catalase activity and the relationship of blood catalase and beta-thalassemia gene mutations. Methods: Blood catalase activity, hemoglobin, HbA 2, HbF, and beta-globin gene mutations were determined in 43 Hungarian patients with beta-thalassemia trait. Results: Compared to controls, the beta-thalassemia trait patients showed a low mean (P2 determination showed high sensitivity and specificity for the detection of beta-thalassemia trait patients. Mutation analyses revealed 13 beta-thalassemia trait mutations, of which six have not been reported before in Hungarian beta-thalassemia trait patients. Each group of mutations revealed decreased (P

Original languageEnglish
Pages (from-to)172-178
Number of pages7
JournalInternational Journal of Laboratory Hematology
Volume34
Issue number2
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Hungary
beta-Thalassemia
Catalase
Blood
Mutation
Genes
beta-Globins
Oxidative stress
Hydrogen Peroxide
Hemoglobins
Thalassemia
Oxidative Stress
Enzymes
Erythrocytes
Sensitivity and Specificity

Keywords

  • Beta-globin gene
  • Blood catalase
  • Blood hemoglobin
  • HbA
  • HbF

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Hematology

Cite this

Decreased blood catalase activity is not related to specific beta-thalassemia mutations in Hungary. / Kósa, Z.; Nagy, T.; Nagy, E.; Fazakas, F.; Góth, L.

In: International Journal of Laboratory Hematology, Vol. 34, No. 2, 04.2012, p. 172-178.

Research output: Contribution to journalArticle

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