Decreased beta2 adrenergic mediated venodilatation in Native Americans

Z. Vajó, E. Cruz, B. Székács, W. Dachman

Research output: Contribution to journalArticle

Abstract

Background. A considerable body of research has been accumulated regarding the pathogenesis and treatment of hypertension in Whites (Caucasians) and in Blacks. This research has led to more effective therapies geared specifically towards these ethnic groups. Unfortunately, very little information is available regarding the pathogenesis of hypertension and the effect of antihypertensive treatment in Native Americans (North-American Indians). Ethnic variability in the response to adrenergic mediated stimulation has been previously described, and reduced compliance of the venous system has been suggested among the possible mechanisms responsible for essential hypertension. The aim of this study was to compare venous responsiveness between Native Americans and Whites to vasoactive substances. Methods. The α1-adrenergic agonist, phenylephrine and the β2-adrenergic agonist isoproterenol were studied in 10 Native American and White volunteers. The dorsal hand vein technique was used, which is a simple, relatively non-invasive method to study the response to vasoactive substances, in vivo. Results. The maximal venodilatory response to isoproterenol in the Native American group was 53.2±27.5%; while in the White group it was 103.4±66.0% (p

Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalInternational Dental Journal
Volume50
Issue number6 SUPPL. 1
Publication statusPublished - 2000

Fingerprint

North American Indians
Adrenergic Agents
Adrenergic Agonists
Isoproterenol
Hypertension
Phenylephrine
Ethnic Groups
Research
Antihypertensive Agents
Compliance
Volunteers
Veins
Therapeutics
Hand

Keywords

  • Caucasoid race
  • Hypertension therapy
  • Indians, North American

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Decreased beta2 adrenergic mediated venodilatation in Native Americans. / Vajó, Z.; Cruz, E.; Székács, B.; Dachman, W.

In: International Dental Journal, Vol. 50, No. 6 SUPPL. 1, 2000, p. 276-281.

Research output: Contribution to journalArticle

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