Decreased antibody-dependent and spontaneous cell-mediated cytotoxicity in patients with chronic renal failure

István Láng, István Taraba, Gyula Petrányi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Antibody-dependent and spontaneous lymphocytotoxicity of blood mononuclear cells from 15 patients with chronic renal failure was studied in allogeneic K-562 and xenogeneic chicken erythrocyte test systems. Both antibody-dependent and spontaneous cytotoxic activities were significantly decreased in uremic patients as compared to the corresponding mean values of healthy control persons and non-uremic patients with the same underlying diseases. The addition of autologous serum further reduced the impaired cytotoxic capacity of uremic lymphocytes. Uremic sera also inhibited the antibody-dependent and spontaneous lymphocytotoxicity of healthy individuals.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalImmunology letters
Volume3
Issue number5
DOIs
Publication statusPublished - Nov 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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