Chronic liver injuries regularly cause liver fibrosis and cirrhosis. These alterations develop as a consequence of imbalance of extracellular matrix synthesis and degradation. The activation of matrix production starts in the early phase of the disease. Decorin has been proven to regulate extracellular matrix assembly as it binds and neutralizes TGF-β1, and effects the maturation of collagen fibers. Decorin is a sensitive detector of chronic hepatitis. Alpha interferon (IFN- α) treatment for one year effectively inhibited the decorin deposition, especially in the portal and perivenular regions, which are the main sites of the inflammatory process. This raises the possibility that INF-α acts via a TGFβ mediated route. Decorin has been reported to be capable of inhibiting the biological activity of TGF-β1, especially in matrix production.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)