Death cap (Amanita phalloïdes) and fool's mushroom (Amanita verna) are the most important amatoxin containing mushrooms in Central-Europe. These toxins belong to the cyclic octapeptides; their chemical structure (as triptathionin) is unusual, they have a great stability (against heat, acids and digestive enzymes). Humans and mammals are very susceptible, other animal groups show lower susceptibility (based on respective LD50 values). Animal poisonings are summarized from the literature, of which the main problems are massive liver and kidney damage with high mortality. Amatoxin molecules inhibit the activity of RNA polymerase II. enzyme producing a stable complex between the toxin and the enzyme. Principles of the therapy are given: importance of a rapid identification of the type of poisoning (of mushroom species), significance of starting the therapy as early as possible and the role of natural molecules for the protection of the liver.
|Translated title of the contribution||Death cap poisoning and the animals. Literature review|
|Number of pages||9|
|Journal||Magyar Allatorvosok Lapja|
|Publication status||Published - Dec 1 2014|
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