Deactivation of T-2 toxin in broiler ducks by biotransformation

J. Kutasi, Z. Papp, L. Jakab, E. Brydl, P. Rafai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Effects of 2 dietary levels (0.6 and 1.0 ppm) of T-2 toxin, and the possible protective capacity of a mycotoxin-inactivating feed additive (Detoxa Plus) were investigated in growing White Pekin ducklings in a 49-d trial comprising 6 treatment groups of 10 ducks/group. The experimental design consisted of 1 negative and 1 positive control and 4 test groups, as follows: group 1, negative control (no T-2 toxin and no feed additive added to the feeds); group 2, positive control (no T-2 toxin added, but the feeds were supplemented with feed additive at 2 kg/t); group 3, feeds were complemented with 0.6 ppm of purified T-2 toxin (no feed additive added); group 4, feeds were complemented with 0.6 ppm of T-2 toxin and 2 kg/t of the feed additive was provided; group 5, feeds were complemented with 1.0 ppm of T-2 toxin (no feed additive added); group 6, feeds were complemented with 1.0 ppm of T-2 toxin and 2 kg/t of the feed additive was provided. From wk 4 until the end of the trial, the daily BW gain of group 3 ducks was inferior to that of control ducks, and the differences in means were statistically significant (P ≤ 0.05) at wk 4 and 7. The final BW of this group was also significantly lower than that of the control (P ≤ 0.001). The BW gain of ducks in group 5 was also depressed by the toxin treatment. The adverse effect of 0.6 ppm of T-2 toxin was fully counteracted by the feed additive in terms of daily BW gain, cumulative daily BW gain, and BW at exsanguination. The T-2 toxin at both treatment levels depressed the blastogenic response of lymphocytes to nonspecific mitogens (concanavalin A and phytohaemagglutinin), which was counteracted by the feed additive at the lower dietary concentration of T-2 toxin. No such effect was observed with 1.0 ppm of T-2 toxin. Metabolic blood parameters and hematological data showed no consistent treatment effects. We conclude that this feed additive is able to counteract the adverse effects of T-2 toxin at dietary concentrations that might be encountered under field conditions.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalJournal of Applied Poultry Research
Volume21
Issue number1
DOIs
Publication statusPublished - Mar 2012

Fingerprint

T-2 toxin
biotransformation
ducks
feed additives
broiler chickens
adverse effects
Pekin
ducklings
phytohemagglutinin
concanavalin A
mycotoxins
toxins
lymphocytes
experimental design

Keywords

  • Broiler duck
  • Mycotoxin control
  • Mycotoxin inactivation
  • T-2 toxin

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Deactivation of T-2 toxin in broiler ducks by biotransformation. / Kutasi, J.; Papp, Z.; Jakab, L.; Brydl, E.; Rafai, P.

In: Journal of Applied Poultry Research, Vol. 21, No. 1, 03.2012, p. 13-20.

Research output: Contribution to journalArticle

Kutasi, J. ; Papp, Z. ; Jakab, L. ; Brydl, E. ; Rafai, P. / Deactivation of T-2 toxin in broiler ducks by biotransformation. In: Journal of Applied Poultry Research. 2012 ; Vol. 21, No. 1. pp. 13-20.
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abstract = "Effects of 2 dietary levels (0.6 and 1.0 ppm) of T-2 toxin, and the possible protective capacity of a mycotoxin-inactivating feed additive (Detoxa Plus) were investigated in growing White Pekin ducklings in a 49-d trial comprising 6 treatment groups of 10 ducks/group. The experimental design consisted of 1 negative and 1 positive control and 4 test groups, as follows: group 1, negative control (no T-2 toxin and no feed additive added to the feeds); group 2, positive control (no T-2 toxin added, but the feeds were supplemented with feed additive at 2 kg/t); group 3, feeds were complemented with 0.6 ppm of purified T-2 toxin (no feed additive added); group 4, feeds were complemented with 0.6 ppm of T-2 toxin and 2 kg/t of the feed additive was provided; group 5, feeds were complemented with 1.0 ppm of T-2 toxin (no feed additive added); group 6, feeds were complemented with 1.0 ppm of T-2 toxin and 2 kg/t of the feed additive was provided. From wk 4 until the end of the trial, the daily BW gain of group 3 ducks was inferior to that of control ducks, and the differences in means were statistically significant (P ≤ 0.05) at wk 4 and 7. The final BW of this group was also significantly lower than that of the control (P ≤ 0.001). The BW gain of ducks in group 5 was also depressed by the toxin treatment. The adverse effect of 0.6 ppm of T-2 toxin was fully counteracted by the feed additive in terms of daily BW gain, cumulative daily BW gain, and BW at exsanguination. The T-2 toxin at both treatment levels depressed the blastogenic response of lymphocytes to nonspecific mitogens (concanavalin A and phytohaemagglutinin), which was counteracted by the feed additive at the lower dietary concentration of T-2 toxin. No such effect was observed with 1.0 ppm of T-2 toxin. Metabolic blood parameters and hematological data showed no consistent treatment effects. We conclude that this feed additive is able to counteract the adverse effects of T-2 toxin at dietary concentrations that might be encountered under field conditions.",
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AU - Brydl, E.

AU - Rafai, P.

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N2 - Effects of 2 dietary levels (0.6 and 1.0 ppm) of T-2 toxin, and the possible protective capacity of a mycotoxin-inactivating feed additive (Detoxa Plus) were investigated in growing White Pekin ducklings in a 49-d trial comprising 6 treatment groups of 10 ducks/group. The experimental design consisted of 1 negative and 1 positive control and 4 test groups, as follows: group 1, negative control (no T-2 toxin and no feed additive added to the feeds); group 2, positive control (no T-2 toxin added, but the feeds were supplemented with feed additive at 2 kg/t); group 3, feeds were complemented with 0.6 ppm of purified T-2 toxin (no feed additive added); group 4, feeds were complemented with 0.6 ppm of T-2 toxin and 2 kg/t of the feed additive was provided; group 5, feeds were complemented with 1.0 ppm of T-2 toxin (no feed additive added); group 6, feeds were complemented with 1.0 ppm of T-2 toxin and 2 kg/t of the feed additive was provided. From wk 4 until the end of the trial, the daily BW gain of group 3 ducks was inferior to that of control ducks, and the differences in means were statistically significant (P ≤ 0.05) at wk 4 and 7. The final BW of this group was also significantly lower than that of the control (P ≤ 0.001). The BW gain of ducks in group 5 was also depressed by the toxin treatment. The adverse effect of 0.6 ppm of T-2 toxin was fully counteracted by the feed additive in terms of daily BW gain, cumulative daily BW gain, and BW at exsanguination. The T-2 toxin at both treatment levels depressed the blastogenic response of lymphocytes to nonspecific mitogens (concanavalin A and phytohaemagglutinin), which was counteracted by the feed additive at the lower dietary concentration of T-2 toxin. No such effect was observed with 1.0 ppm of T-2 toxin. Metabolic blood parameters and hematological data showed no consistent treatment effects. We conclude that this feed additive is able to counteract the adverse effects of T-2 toxin at dietary concentrations that might be encountered under field conditions.

AB - Effects of 2 dietary levels (0.6 and 1.0 ppm) of T-2 toxin, and the possible protective capacity of a mycotoxin-inactivating feed additive (Detoxa Plus) were investigated in growing White Pekin ducklings in a 49-d trial comprising 6 treatment groups of 10 ducks/group. The experimental design consisted of 1 negative and 1 positive control and 4 test groups, as follows: group 1, negative control (no T-2 toxin and no feed additive added to the feeds); group 2, positive control (no T-2 toxin added, but the feeds were supplemented with feed additive at 2 kg/t); group 3, feeds were complemented with 0.6 ppm of purified T-2 toxin (no feed additive added); group 4, feeds were complemented with 0.6 ppm of T-2 toxin and 2 kg/t of the feed additive was provided; group 5, feeds were complemented with 1.0 ppm of T-2 toxin (no feed additive added); group 6, feeds were complemented with 1.0 ppm of T-2 toxin and 2 kg/t of the feed additive was provided. From wk 4 until the end of the trial, the daily BW gain of group 3 ducks was inferior to that of control ducks, and the differences in means were statistically significant (P ≤ 0.05) at wk 4 and 7. The final BW of this group was also significantly lower than that of the control (P ≤ 0.001). The BW gain of ducks in group 5 was also depressed by the toxin treatment. The adverse effect of 0.6 ppm of T-2 toxin was fully counteracted by the feed additive in terms of daily BW gain, cumulative daily BW gain, and BW at exsanguination. The T-2 toxin at both treatment levels depressed the blastogenic response of lymphocytes to nonspecific mitogens (concanavalin A and phytohaemagglutinin), which was counteracted by the feed additive at the lower dietary concentration of T-2 toxin. No such effect was observed with 1.0 ppm of T-2 toxin. Metabolic blood parameters and hematological data showed no consistent treatment effects. We conclude that this feed additive is able to counteract the adverse effects of T-2 toxin at dietary concentrations that might be encountered under field conditions.

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