Daunorubicin and doxorubicin inhibit the [11C]choline accumulation in cancer cells

Pál Mikecz, Teréz Márián, Tünde Miklovicz, László Galuska, Zoltán Krasznai, Ágnes Tóth, Katalin Goda, Lajos Trón, Zoltán Hernádi, Zoárd T. Krasznai

Research output: Contribution to journalArticle

Abstract

We studied how very short (10-40 min) incubation with anthracycline derivatives modifies the accumulation of PET tumor-diagnostic radiotracers in cancer cells. The human ovarian A2780 and A2780AD, human B lymphoid JY, human epidermoid KB-3-1 and KB-V-1, and smooth muscle DDT1 MF-2 cells were pre-incubated with daunorubicin and doxorubicin, and the uptake of [18F]FDG and [11C]choline was measured. Anthracycline treatment decreased remarkably the [11C]choline accumulation in a concentration dependent manner, while it did not modify significantly the [18F]FDG uptake of the cells.

Original languageEnglish
Pages (from-to)1806-1811
Number of pages6
JournalApplied Radiation and Isotopes
Volume67
Issue number10
DOIs
Publication statusPublished - Oct 1 2009

    Fingerprint

Keywords

  • Cancer cells
  • Daunorubicin
  • Doxorubicin
  • P-glycoprotein
  • PET
  • [C]choline
  • [F]FDG

ASJC Scopus subject areas

  • Radiation

Cite this