Data-Driven Identification of Stochastic Model Parameters and State Variables: Application to the Study of Cardiac Beat-to-Beat Variability

David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, Laszlo Virag, Andras Varro, Esther Pueyo

Research output: Contribution to journalArticle

Abstract

Enhanced spatiotemporal ventricular repolarization variability has been associated with ventricular arrhythmias and sudden cardiac death, but the involved mechanisms remain elusive. In this paper, a methodology for estimation of parameters and state variables of stochastic human ventricular cell models from input voltage data is proposed for investigation of repolarization variability. Methods: The proposed methodology formulates state-space representations based on developed stochastic cell models and uses the unscented Kalman filter to perform joint parameter and state estimation. Evaluation over synthetic and experimental data is presented. Results: Results on synthetically generated data show the ability of the methodology to: first, filter out measurement noise from action potential (AP) traces; second, identify model parameters and state variables from each of those individual AP traces, thus allowing robust characterization of cell-to-cell variability; and, third, replicate statistical population's distributions of input AP-based markers, including dynamic markers quantifying beat-to-beat variability. Application onto experimental data demonstrates the ability of the methodology to match input AP traces while concomitantly inferring the characteristics of underlying stochastic cell models. Conclusion: A novel methodology is presented for estimation of parameters and hidden variables of stochastic cardiac computational models, with the advantage of providing a one-to-one match between each individual AP trace and a corresponding set of model characteristics. Significance: The proposed methodology can greatly help in the characterization of temporal (beat-to-beat) and spatial (cell-to-cell) variability in human ventricular repolarization and in ascertaining the corresponding underlying mechanisms, particularly in scenarios with limited available experimental data.

Original languageEnglish
Article number8733819
Pages (from-to)693-704
Number of pages12
JournalIEEE Journal of Biomedical and Health Informatics
Volume24
Issue number3
DOIs
Publication statusPublished - Mar 2020

Keywords

  • beat-to-beat variability
  • Cardiac electrophysiological models
  • joint estimation
  • parameter estimation
  • unscented Kalman filter

ASJC Scopus subject areas

  • Biotechnology
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Health Information Management

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