DAT1 gene polymorphism in alcoholism: A family-based association study

Petra Franke, Sibylle G. Schwab, Michael Knapp, Michael Gänsicke, Cynthia Delmo, Peter Zill, M. Trixler, Dirk Lichtermann, Joachim Hallmayer, Dieter B. Wildenauer, Wolfgang Maier

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1; SLC6A3) is more frequent in alcohol-dependent probands-and in particular those with severe withdrawal symptoms (seizures and/or delirium)-compared to nonalcoholics. Methods: To avoid stratification effects, the family-based association approach of Falk and Rubinstein was used in our sample of 87 alcohol-dependent probands and their biological parents. Results: By applying a family-based association approach, we were not able to detect significant association between allele 9 at DAT1 (SLC6A3) and alcoholism as well as between patients with or without severe withdrawal symptoms. Conclusions: Based on our data, the impact of the 9-repeat allele of the dopamine transporter gene in alcoholism and the severity of alcohol withdrawal symptoms is putatively not substantial.

Original languageEnglish
Pages (from-to)652-654
Number of pages3
JournalBiological Psychiatry
Volume45
Issue number5
DOIs
Publication statusPublished - Mar 1 1999

Fingerprint

Substance Withdrawal Syndrome
Alcoholism
Dopamine Plasma Membrane Transport Proteins
Alleles
Alcohols
Genes
Delirium
Seizures
Parents

Keywords

  • Alcoholism
  • Delirium
  • Dopamine transporter (SLC6A3)
  • Family-based association study
  • Seizure
  • Withdrawal

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Franke, P., Schwab, S. G., Knapp, M., Gänsicke, M., Delmo, C., Zill, P., ... Maier, W. (1999). DAT1 gene polymorphism in alcoholism: A family-based association study. Biological Psychiatry, 45(5), 652-654. https://doi.org/10.1016/S0006-3223(98)00135-8

DAT1 gene polymorphism in alcoholism : A family-based association study. / Franke, Petra; Schwab, Sibylle G.; Knapp, Michael; Gänsicke, Michael; Delmo, Cynthia; Zill, Peter; Trixler, M.; Lichtermann, Dirk; Hallmayer, Joachim; Wildenauer, Dieter B.; Maier, Wolfgang.

In: Biological Psychiatry, Vol. 45, No. 5, 01.03.1999, p. 652-654.

Research output: Contribution to journalArticle

Franke, P, Schwab, SG, Knapp, M, Gänsicke, M, Delmo, C, Zill, P, Trixler, M, Lichtermann, D, Hallmayer, J, Wildenauer, DB & Maier, W 1999, 'DAT1 gene polymorphism in alcoholism: A family-based association study', Biological Psychiatry, vol. 45, no. 5, pp. 652-654. https://doi.org/10.1016/S0006-3223(98)00135-8
Franke P, Schwab SG, Knapp M, Gänsicke M, Delmo C, Zill P et al. DAT1 gene polymorphism in alcoholism: A family-based association study. Biological Psychiatry. 1999 Mar 1;45(5):652-654. https://doi.org/10.1016/S0006-3223(98)00135-8
Franke, Petra ; Schwab, Sibylle G. ; Knapp, Michael ; Gänsicke, Michael ; Delmo, Cynthia ; Zill, Peter ; Trixler, M. ; Lichtermann, Dirk ; Hallmayer, Joachim ; Wildenauer, Dieter B. ; Maier, Wolfgang. / DAT1 gene polymorphism in alcoholism : A family-based association study. In: Biological Psychiatry. 1999 ; Vol. 45, No. 5. pp. 652-654.
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