Damaging actions of testosterone on cysteamine-induced gastroduodenal ulceration and vascular leakage in the rat

Ferenc László, Csaba Varga, Corrado Montoneri, Filippo Drago

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8 Citations (Scopus)

Abstract

The sexual dimorphism of gastroduodenal ulceration is suggested on the basis of clinical and experimental observations. This difference probably relates to the actions of endogenous sexual steroids. In the present study, the role of testosterone was evaluated in the generation of gastroduodenal mucosal injury provoked by cysteamine (400 mg/kg, s.c.). We found that macroscopic mucosal damage and microvascular 125I-human serum albumin leakage (2 μCi/kg, i.v.) developed in the stomach and duodenum of male rats 24 h after the administration of cysteamine. This mucosal injury was prevented by orchidectomy and by the pretreatment with the antiandrogen, cyproterone acetate (12 mg/kg per day for 8 consecutive days). It was also shown that pretreatment with testosterone (4-20 mg/kg per week) dose-dependently aggravated cysteamine-induced gastroduodenal mucosal injury. Our results thus suggest an aggressive role of testosterone in the generation of cysteamine-induced gastroduodenal ulceration.

Original languageEnglish
Pages (from-to)275-278
Number of pages4
JournalEuropean Journal of Pharmacology
Volume337
Issue number2-3
DOIs
Publication statusPublished - Oct 22 1997

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Keywords

  • Cysteamine
  • Gastroduodenal mucosa
  • Gastroduodenal ulceration
  • Microcirculation
  • Microvascular leakage
  • Sexual dimorphism
  • Sexual steroid
  • Testosterone

ASJC Scopus subject areas

  • Pharmacology

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