Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice

János F. László, Judit Szilvási, Anett Fényi, Andrea Szalai, Klára Gyires, Róbert Pórszász

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: The present study was designed to reveal, whether the 30min daily full body exposure of mice to an inhomogeneous static magnetic field (SMF) has a statistically significant effect on diabetic neuropathy. Materials and methods: Three different doses (100, 150, or 200 mg/kg) of streptozotocin (STZ) were administered intraperitoneally in groups of mice to induce diabetes. Body weight, blood glucose level and the nociceptive temperature threshold of mice were monitored for a period of 12 weeks. The group treated with 200 mg/kg i.p. STZ produced manifest diabetic neuropathy. Results were compared to non-treated (no SMF, no STZ) and SMF exposure without STZ-treatment group (SMF, no STZ) group. The inhomogeneous SMF was in the range of 2.8-476.7 mT peak-to-peak magnetic flux density. Results: Whereas SMF exposure did not seem to affect body weight and nociceptive temperature threshold, it statistically significantly (p < 0.001) reduced blood glucose level in the 200 mg/kg STZ (n = 6) group. Conclusions: Daily SMF exposure repeated for several weeks is protective against the development of high blood glucose level in diabetic mice.

Original languageEnglish
Pages (from-to)36-45
Number of pages10
JournalInternational Journal of Radiation Biology
Volume87
Issue number1
DOIs
Publication statusPublished - Jan 1 2011

Keywords

  • diabetes
  • mouse
  • neuropathia diabetica
  • neuropathy
  • static magnetic field (SMF)
  • streptozotocin (STZ)

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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