Purpose: The present study was designed to reveal, whether the 30min daily full body exposure of mice to an inhomogeneous static magnetic field (SMF) has a statistically significant effect on diabetic neuropathy. Materials and methods: Three different doses (100, 150, or 200 mg/kg) of streptozotocin (STZ) were administered intraperitoneally in groups of mice to induce diabetes. Body weight, blood glucose level and the nociceptive temperature threshold of mice were monitored for a period of 12 weeks. The group treated with 200 mg/kg i.p. STZ produced manifest diabetic neuropathy. Results were compared to non-treated (no SMF, no STZ) and SMF exposure without STZ-treatment group (SMF, no STZ) group. The inhomogeneous SMF was in the range of 2.8-476.7 mT peak-to-peak magnetic flux density. Results: Whereas SMF exposure did not seem to affect body weight and nociceptive temperature threshold, it statistically significantly (p < 0.001) reduced blood glucose level in the 200 mg/kg STZ (n = 6) group. Conclusions: Daily SMF exposure repeated for several weeks is protective against the development of high blood glucose level in diabetic mice.
- neuropathia diabetica
- static magnetic field (SMF)
- streptozotocin (STZ)
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging