d-pipecolic acid inhibits ethanol tolerance in mice

Gyula Szabó, Gábor L. Kovács, Lajos Baláspiri, Gyula Telegdy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effects of graded doses of d-pipecolic acid (0.005-5 μg/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice. d-pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeated d-pipecolic acid administration, however, blocked the development of tolerance to the hypothermic effect of ethanol. The development of tolerance could be observed in the control group. It is assumed that d-pipecolic acid is capable of counteracting the tolerance effect of ethanol.

Original languageEnglish
Pages (from-to)1677-1682
Number of pages6
JournalNeurochemical research
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 1 1986

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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