The effects of graded doses of d-pipecolic acid (0.005-5 μg/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice. d-pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeated d-pipecolic acid administration, however, blocked the development of tolerance to the hypothermic effect of ethanol. The development of tolerance could be observed in the control group. It is assumed that d-pipecolic acid is capable of counteracting the tolerance effect of ethanol.
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience