(d-Met2,Pro5)Enkephalinamide causes a decrease in plasma prolactin levels of lactating rats continuously suckled and an increase in those deprived of their litter

Gy Nagy, L. Takács, B. Halász

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6 Citations (Scopus)


The effect of an enkephalin analogue, (d-Met2,Pro5)enkephalinamide (EKNH2) on prolactin (PRL) secretion of lactating rats continuously suckled or separated from their pups was investigated. In rats together with their pups 0.5 mg/kg EKNH2 caused a dramatic decrease, 0.25 mg/kg a mild and short-lasting reduction in plasma PRL levels. In contrast, in lactating rats separated for 4 h from their pups 0.5 mg/kg of the drug induced a slight and 1.0 mg/kg a considerable increase in plasma PRL levels. The data indicate that in lactating rats depending on the circumstances the enkephalin analogue causes opposite effects on PRL secretion.

Original languageEnglish
Pages (from-to)321-326
Number of pages6
JournalRegulatory Peptides
Issue number4
Publication statusPublished - Jul 1984



  • enkephalin analogue
  • lactating rat
  • prolactin
  • suckling or separation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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