[D-Met2,Pro5]enkephalinamide and dynorphin-(1-13) inhibit the cholinergic contraction induced in the guinea-pig ileum by substance P

Peter Holzer, Irmgard Th Lippe, Loránd Barthó, Fred Lembeck

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7 Citations (Scopus)


In the isolated guinea-pig ileum, the sustained phase of the longitudinal contractile response to substance P is, unlike the initial peak response, mediated by stimulation of cholinergic neurons. This cholinergically mediated response to substance P was inhibited by the specific substance P antagonist, [D-Pro2,D-Trp7,9]substance P, which suggests that substance P stimulates enteric cholinergic neurons through a specific site of action. [D-Met2,Pro5]enkephalinamide and dynorphin-(1-13) also decreased whereas naloxone increased the sustained response to substance P. The results indicate that the enteric cholinergic neurons, which are stimulated by subtance P, are also under the control of enkephalin and/or dynorphin neurons.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalEuropean Journal of Pharmacology
Issue number1
Publication statusPublished - Jul 15 1983



  • Dynorphin-(1-13)
  • Enkephalin
  • Guinea-pig ileum
  • Naloxone
  • Substance P contraction

ASJC Scopus subject areas

  • Pharmacology

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