Cytotoxicity of a transferrin-adriamycin conjugate to anthracycline-resistant cells

M. Fritzer, K. Barabas, V. Szűts, A. Bérczi, T. Szekeres, W. P. Faulk, H. Goldenberg

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Conjugates of adriamycin coupled to transferrin by glutaraldehyde are cytotoxic to human promyelocytic (HL-60) and erythroleukemic (K562) cells. Growth inhibition of adriamycin-sensitive cells, as evaluated by thymidine incorporation and the MTT-assay, was higher for conjugates than for free adriamycin. The cytotoxicity toward adriamycin-resistant K562 and HL-60 cells was 3-fold and more than 10-fold higher, respectively, for the transferrin-adriamycin conjugate than for the free drug. The effect of the conjugate was dependent on its adriamycin content, i.e., on its conjugation number.

Original languageEnglish
Pages (from-to)619-623
Number of pages5
JournalInternational Journal of Cancer
Volume52
Issue number4
DOIs
Publication statusPublished - 1992

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Anthracyclines
Transferrin
Doxorubicin
K562 Cells
HL-60 Cells
Glutaral
Thymidine
Growth
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cytotoxicity of a transferrin-adriamycin conjugate to anthracycline-resistant cells. / Fritzer, M.; Barabas, K.; Szűts, V.; Bérczi, A.; Szekeres, T.; Faulk, W. P.; Goldenberg, H.

In: International Journal of Cancer, Vol. 52, No. 4, 1992, p. 619-623.

Research output: Contribution to journalArticle

Fritzer, M. ; Barabas, K. ; Szűts, V. ; Bérczi, A. ; Szekeres, T. ; Faulk, W. P. ; Goldenberg, H. / Cytotoxicity of a transferrin-adriamycin conjugate to anthracycline-resistant cells. In: International Journal of Cancer. 1992 ; Vol. 52, No. 4. pp. 619-623.
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