Cytotoxicities and anti-Herpes simplex virus activities of diterpenes isolated from Euphorbia species

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Abstract

The cytotoxicities of nine diterpene polyesters obtained from Euphorbia species were assayed by measuring their effects on the growth of Vero cells. Their antiviral effects on the multiplication of Herpes simplex virus type 2 (HSV-2) were studied by using the virus yield reduction method in cell cultures. With the exception of the strongly cytotoxic 2α,5α,14β-triacetoxy-3β-benzoyloxy- 8α,15β-dihydroxy-7β-isobutanoyloxy-9α- nicotinoyloxyjatropha-6(17),11E-diene (CC50 3.5 μg/ml), all the tested diterpenes exhibited a pronounced or moderate anti-herpes virus effect (IC50 values between 2.5 and 8.3 μg/ml). The observed HSV-2 inhibitory activities were not associated with virucidal effects.

Original languageEnglish
Pages (from-to)672-674
Number of pages3
JournalPlanta Medica
Volume67
Issue number7
DOIs
Publication statusPublished - 2001

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Human herpesvirus 2
Euphorbia
herpes simplex
Human Herpesvirus 2
Diterpenes
Simplexvirus
Cytotoxicity
Viruses
diterpenoids
cytotoxicity
viruses
Vero Cells
Polyesters
polyesters
Inhibitory Concentration 50
Antiviral Agents
inhibitory concentration 50
cell culture
Cell Culture Techniques
Growth

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

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title = "Cytotoxicities and anti-Herpes simplex virus activities of diterpenes isolated from Euphorbia species",
abstract = "The cytotoxicities of nine diterpene polyesters obtained from Euphorbia species were assayed by measuring their effects on the growth of Vero cells. Their antiviral effects on the multiplication of Herpes simplex virus type 2 (HSV-2) were studied by using the virus yield reduction method in cell cultures. With the exception of the strongly cytotoxic 2α,5α,14β-triacetoxy-3β-benzoyloxy- 8α,15β-dihydroxy-7β-isobutanoyloxy-9α- nicotinoyloxyjatropha-6(17),11E-diene (CC50 3.5 μg/ml), all the tested diterpenes exhibited a pronounced or moderate anti-herpes virus effect (IC50 values between 2.5 and 8.3 μg/ml). The observed HSV-2 inhibitory activities were not associated with virucidal effects.",
author = "I. Mucsi and J. Moln{\'a}r and J. Hohmann and D. R{\'e}dei",
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language = "English",
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T1 - Cytotoxicities and anti-Herpes simplex virus activities of diterpenes isolated from Euphorbia species

AU - Mucsi, I.

AU - Molnár, J.

AU - Hohmann, J.

AU - Rédei, D.

PY - 2001

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AB - The cytotoxicities of nine diterpene polyesters obtained from Euphorbia species were assayed by measuring their effects on the growth of Vero cells. Their antiviral effects on the multiplication of Herpes simplex virus type 2 (HSV-2) were studied by using the virus yield reduction method in cell cultures. With the exception of the strongly cytotoxic 2α,5α,14β-triacetoxy-3β-benzoyloxy- 8α,15β-dihydroxy-7β-isobutanoyloxy-9α- nicotinoyloxyjatropha-6(17),11E-diene (CC50 3.5 μg/ml), all the tested diterpenes exhibited a pronounced or moderate anti-herpes virus effect (IC50 values between 2.5 and 8.3 μg/ml). The observed HSV-2 inhibitory activities were not associated with virucidal effects.

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