Cytotoxic T lymphocyte-associated antigen +49g variant confers risk for anti-CCP- and rheumatoid factor-positive type of rheumatoid arthritis only in combination with CT60* G allele

Bernadett Farago, Peter Kisfali, Lili Magyari, Noemi Polgar, Bela Melegh

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Abstract

Controversial observations have been published on the association of the cytotoxic T lymphocyte associated antigen gene's variants with rheumatoid arthritis (RA). After genotyping 428 patients and 230 matched controls, the prevalence of the CT*60 G allele was more frequent in RF- and/or anti-CCP-seropositive RApatients, compared to the healthy controls (P <.001). Regression analysis revealed that the CT60*G allele is a possible predisposing factor for RA in these subgroups. No accumulation of the + 49*G allele was found among patients, and this variant was not found to correlate with RA. Assaying the possible genotype variations, the + 49*G- C T 60*G allelic combination was accumulated in seropositive RA-subtypes, and was associated with the risk of RA (OR = 1.73, P =.001 for the whole RA-population). Although the + 49*G allele did not mean a predisposition to RA alone, in combination with C T 60*G it, also conferred risk, suggesting that the + 49 A / G variant is associated with the risk of RA only in certain haplotypes.

Original languageEnglish
Article number285974
JournalAutoimmune Diseases
Volume1
Issue number1
DOIs
Publication statusPublished - Dec 1 2010

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Immunology and Microbiology (miscellaneous)

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