Cytotoxic diterpene quinones from Salvia tebesana Bunge

Samira Eghbaliferiz, Seyed Ahmad Emami, Zahra Tayarani-Najaran, Mehrdad Iranshahi, Abolfazl Shakeri, J. Hohmann, Javad Asili

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A phytochemical investigation of the root extracts of Salvia tebesana Bunge led to the isolation of two new diterpenoids, tebesinone A (1) and tebesinone B (2), along with two known compounds, aegyptinone A (3) and aegyptinone B (4). The structures were established by spectroscopic analysis including 1D and 2D NMR and HRESIMS. The cytotoxic activities of the crude extracts and isolated compounds were evaluated against MCF-7, B16F10, PC-3 and C26 human cancer cell lines, in which compounds 2 and 3 showed significant cytotoxic activities (IC50 2.1–10.3 μM).

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalFitoterapia
Volume128
DOIs
Publication statusPublished - Jul 1 2018

Keywords

  • Abietane diterpenoids
  • Cytotoxic activity
  • Salvia tebesana
  • Structure elucidation

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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  • Cite this

    Eghbaliferiz, S., Emami, S. A., Tayarani-Najaran, Z., Iranshahi, M., Shakeri, A., Hohmann, J., & Asili, J. (2018). Cytotoxic diterpene quinones from Salvia tebesana Bunge. Fitoterapia, 128, 97-101. https://doi.org/10.1016/j.fitote.2018.05.005