Cytotoxic diterpene quinones from Salvia tebesana Bunge

Samira Eghbaliferiz, Seyed Ahmad Emami, Zahra Tayarani-Najaran, Mehrdad Iranshahi, Abolfazl Shakeri, J. Hohmann, Javad Asili

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A phytochemical investigation of the root extracts of Salvia tebesana Bunge led to the isolation of two new diterpenoids, tebesinone A (1) and tebesinone B (2), along with two known compounds, aegyptinone A (3) and aegyptinone B (4). The structures were established by spectroscopic analysis including 1D and 2D NMR and HRESIMS. The cytotoxic activities of the crude extracts and isolated compounds were evaluated against MCF-7, B16F10, PC-3 and C26 human cancer cell lines, in which compounds 2 and 3 showed significant cytotoxic activities (IC50 2.1–10.3 μM).

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalFitoterapia
Volume128
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Salvia
Quinones
Diterpenes
Phytochemicals
Complex Mixtures
Inhibitory Concentration 50
Cell Line
Neoplasms
Salvia extract

Keywords

  • Abietane diterpenoids
  • Cytotoxic activity
  • Salvia tebesana
  • Structure elucidation

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Eghbaliferiz, S., Emami, S. A., Tayarani-Najaran, Z., Iranshahi, M., Shakeri, A., Hohmann, J., & Asili, J. (2018). Cytotoxic diterpene quinones from Salvia tebesana Bunge. Fitoterapia, 128, 97-101. https://doi.org/10.1016/j.fitote.2018.05.005

Cytotoxic diterpene quinones from Salvia tebesana Bunge. / Eghbaliferiz, Samira; Emami, Seyed Ahmad; Tayarani-Najaran, Zahra; Iranshahi, Mehrdad; Shakeri, Abolfazl; Hohmann, J.; Asili, Javad.

In: Fitoterapia, Vol. 128, 01.07.2018, p. 97-101.

Research output: Contribution to journalArticle

Eghbaliferiz, S, Emami, SA, Tayarani-Najaran, Z, Iranshahi, M, Shakeri, A, Hohmann, J & Asili, J 2018, 'Cytotoxic diterpene quinones from Salvia tebesana Bunge', Fitoterapia, vol. 128, pp. 97-101. https://doi.org/10.1016/j.fitote.2018.05.005
Eghbaliferiz S, Emami SA, Tayarani-Najaran Z, Iranshahi M, Shakeri A, Hohmann J et al. Cytotoxic diterpene quinones from Salvia tebesana Bunge. Fitoterapia. 2018 Jul 1;128:97-101. https://doi.org/10.1016/j.fitote.2018.05.005
Eghbaliferiz, Samira ; Emami, Seyed Ahmad ; Tayarani-Najaran, Zahra ; Iranshahi, Mehrdad ; Shakeri, Abolfazl ; Hohmann, J. ; Asili, Javad. / Cytotoxic diterpene quinones from Salvia tebesana Bunge. In: Fitoterapia. 2018 ; Vol. 128. pp. 97-101.
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