Cytotoxic compounds from endemic arnebia purpurea

Merve Yuzbasioglu, Ayse Kuruuzum-Uz, Zuhal Guvenalp, András Simon, Gábor Tóth, U. Sebnem Harput, Cavit Kazaz, Bilgehan Bilgili, Hayri Duman, Iclal Saracoglu, L. Omur Demirezer

Research output: Contribution to journalArticle

5 Citations (Scopus)


Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik &H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [â-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-rutinoside, and kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.

Original languageEnglish
Pages (from-to)595-596
Number of pages2
JournalNatural product communications
Issue number4
Publication statusPublished - Jan 1 2015


  • Arnebia purpurea
  • Boraginaceae
  • Cytotoxicity
  • Flavonoids
  • Naphthoquinones
  • Rosmarinic acid
  • Steroids
  • Triterpenes

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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  • Cite this

    Yuzbasioglu, M., Kuruuzum-Uz, A., Guvenalp, Z., Simon, A., Tóth, G., Sebnem Harput, U., Kazaz, C., Bilgili, B., Duman, H., Saracoglu, I., & Omur Demirezer, L. (2015). Cytotoxic compounds from endemic arnebia purpurea. Natural product communications, 10(4), 595-596.