Cytostatic and cytotoxic effects of trigonella foenum graecum (fenugreek) seed extract

Aurel Ardelean, George Pribac, Anca Hermenean, Marika Czapar, Endre Mathe, Liana Moş, Coralia Cotoraci, Ovidiu Bulzan, Constantin Crǎciun

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2 Citations (Scopus)


The antineoplastic effect of Trigonella foenum graecum seed extract has been evaluated in the Ehrlich ascites carcinoma (EAC) model on mice. Intra-peritoneal administration of the plant extract both before and after inoculation of EAC cell in mice produced alterations of ascites cells and inhibition of tumor growth compared to the control. The cytostatic effects on Ehrlich ascites are nuclear and cytoplasmic oedema, nucleoli hypertrophy, expansion of mitochondria and rough endoplasmic reticulum, ribosome detachment, diminishment of smooth endoplasmic reticulum and finally the inhibition of protein and enzymes synthesis. In this study, after the analysis of ultrastructural modifications we observed that the blockage is a reversible process, compatible with the survival of cells; although these cells observed even after 3-4 weeks of treatment that they have lost the malignity property and the ability of entering into mitosis. The alterations observed in the cytoplasm are similar to those we have found in literature: expansion of mitochondria, depletion of ribosomes, increase of lysosomes and lipid drops and picnosis. This effect of blocking the malignity without killing the cells is characterised by ultrastructural mechanisms inducing a rapid senescence. The nuclear inter-membrane space enlarged, the chromatin distribution changes and the cell organelles undergo modifications.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalStudia Universitatis Vasile Goldis Arad, Seria Stiintele Vietii
Issue number1
Publication statusPublished - Mar 10 2010



  • Cytostatic
  • Cytotoxic
  • Ehrlich ascites cells
  • Fenugreek
  • Trigonella foenum graecum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Ardelean, A., Pribac, G., Hermenean, A., Czapar, M., Mathe, E., Moş, L., Cotoraci, C., Bulzan, O., & Crǎciun, C. (2010). Cytostatic and cytotoxic effects of trigonella foenum graecum (fenugreek) seed extract. Studia Universitatis Vasile Goldis Arad, Seria Stiintele Vietii, 20(1), 25-29.