Az alzheimer-kór citoszkeletális változásai: A terápiás remény "váza"?

Translated title of the contribution: Cytoskeletal alterations in Alzheimer's disease: The "skeleton" of therapeutic hope?

Fodor Eszter Klára, M. Pákáski, Sántha Petra, Z. Janka, J. Kálmán

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Damage to and functional alteration of structures responsible for synaptic plasticity correlate with memory loss and cognitive decline in Alzheimer's disease. The results of recent research in the pathomechanism of Alzheimer's disease emphasize the significance of cytoskeletal changes. The changes in actin dynamics and its regulation by actin-binding proteins have been proven in Alzheimer's disease, which may have a key role in the conformation and alteration of synapses and dendritic spines. The most important proteins in the regulation of actin dynamics are ADF/cofilin, kinases and drebrin. In this review, we summarize the physiological functions and complex regulation of these cytoskeletal proteins and their alterations in Alzheimer's disease. Additionally, the effects of some psychopharmacons on the actin cytoskeleton and cytoskeletal changes induced by stress are also summarized.

Original languageHungarian
Pages (from-to)163-171
Number of pages9
JournalNeuropsychopharmacologia Hungarica
Volume13
Issue number3
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Hope
Skeleton
Alzheimer Disease
Actins
Actin Depolymerizing Factors
Microfilament Proteins
Dendritic Spines
Neuronal Plasticity
Cytoskeletal Proteins
Memory Disorders
Therapeutics
Actin Cytoskeleton
Synapses
Phosphotransferases
Research
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

Az alzheimer-kór citoszkeletális változásai : A terápiás remény "váza"? / Klára, Fodor Eszter; Pákáski, M.; Petra, Sántha; Janka, Z.; Kálmán, J.

In: Neuropsychopharmacologia Hungarica, Vol. 13, No. 3, 09.2011, p. 163-171.

Research output: Contribution to journalArticle

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