Cytoprotective effect of (-)-deprenyl, (-)desmethyl-deprenyl and (-)deprenyl-N-oxide on glutathione depleted A-2058 melanoma cells

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Postulated cytoprotective action of (-)-deprenyl (D), (-)-desmethyl- deprenyl (DD) and (-)-deprenyl-N-oxide (DNO) on l-buthionine-(S,R)-sulfoximine (BSO) toxicity was investigated using in vitro cultures of serum-deprived A-2058 melanoma cells. BSO (10 μM/l) decreased viable cell number and mitotic rate, while increased the apoptotic index. D and both of its metabolites, given together with BSO in the concentration of 50 μM/l, mitigated cell loss and decreased the apoptotic ratio. DD was the most effective compound in decreasing apoptotic activity, while DNO stabilized the cell number on control level and increasing the ratio of mitotic cells above the only serum-deprived control. Surveillance on mitochondrial membrane stability and antioxidant properties may play an important role in these processes.

Original languageEnglish
Pages (from-to)695-698
Number of pages4
JournalJournal of neural transmission
Volume117
Issue number6
DOIs
Publication statusPublished - Jun 1 2010

Keywords

  • (-)-Deprenyl
  • Glutathione depletion
  • Melanoma cells
  • Tissue culture
  • l-buthionine-(S,R)-sulfoximine

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Cytoprotective effect of (-)-deprenyl, (-)desmethyl-deprenyl and (-)deprenyl-N-oxide on glutathione depleted A-2058 melanoma cells'. Together they form a unique fingerprint.

  • Cite this