Cytoprotecting-effect of cimetidine: Experimental evidence in the rat gastric mucosal lesions induced by intragastric administration of necrotizing agents

F. Moron, E. Cuesta, M. Bata, G. Mózsik

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Abstract

Contradictory data have been found on cimetidine-induced gastric cytoprotection. In our paper the effect of cimetidine administered intraperitoneally in doses of 2.5, 10 and 50 mg.kg-1, on: (1) the gastric acid secretory responses in 1 and 4 hr pylorus-ligated rats, and (2) the rat gastric mucosal lesions induced by intragastric administration of 0.6 M HCl, 0.2 M NaOH, 96% ethanol and 25% NaCl is discussed. It was found that (1) cimetidine dose-dependently inhibited the gastric acid secretion in 1 and 4 hr pylorus-ligated rats, but a dose of 2.5 mg.kg-1 did not exert any significant inhibition; (2) all doses of cimetidine significantly prevented the gastric lesion development induced by different necrotizing agents (0.65 M HCl, 0.2 M NaOH, 96% ethanol, and 25% NaCl); (3) the cytoprotecting dose of cimetidine was 2.5 mg.kg-1; and (4) the duration of cimetidine-induced cytoprotection was 1 hr long before the administration of the necrotizing agent. These results suggest a real cimetidine-induced gastric cytoprotection.

Original languageEnglish
Pages (from-to)309-319
Number of pages11
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume265
Issue number2
Publication statusPublished - 1983

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Cimetidine
Stomach
Cytoprotection
Gastric Acid
Pylorus
Ethanol

ASJC Scopus subject areas

  • Pharmacology

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title = "Cytoprotecting-effect of cimetidine: Experimental evidence in the rat gastric mucosal lesions induced by intragastric administration of necrotizing agents",
abstract = "Contradictory data have been found on cimetidine-induced gastric cytoprotection. In our paper the effect of cimetidine administered intraperitoneally in doses of 2.5, 10 and 50 mg.kg-1, on: (1) the gastric acid secretory responses in 1 and 4 hr pylorus-ligated rats, and (2) the rat gastric mucosal lesions induced by intragastric administration of 0.6 M HCl, 0.2 M NaOH, 96{\%} ethanol and 25{\%} NaCl is discussed. It was found that (1) cimetidine dose-dependently inhibited the gastric acid secretion in 1 and 4 hr pylorus-ligated rats, but a dose of 2.5 mg.kg-1 did not exert any significant inhibition; (2) all doses of cimetidine significantly prevented the gastric lesion development induced by different necrotizing agents (0.65 M HCl, 0.2 M NaOH, 96{\%} ethanol, and 25{\%} NaCl); (3) the cytoprotecting dose of cimetidine was 2.5 mg.kg-1; and (4) the duration of cimetidine-induced cytoprotection was 1 hr long before the administration of the necrotizing agent. These results suggest a real cimetidine-induced gastric cytoprotection.",
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T2 - Experimental evidence in the rat gastric mucosal lesions induced by intragastric administration of necrotizing agents

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AU - Cuesta, E.

AU - Bata, M.

AU - Mózsik, G.

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