Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells

Eva Gönczöl, Peter W. Andrews, Stanley A. Plotkin

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Abstract

To study the mode of action of human cytomegalovirus, an important teratogenic agent in human populations, the susceptibility of a pluripotent human embryonal carcinoma cell line to the virus was investigated. Viral antigens were not expressed nor was infectious virus produced by human embryonal carcinoma cells after infection, although the virus was able to penetrate these cells. In contrast, retinoic acid-induced differentiated derivatives of embryonal carcinoma cells were permissive for antigen expression and infectious virus production. Replication of human cytomegalovirus in human teratocarcinoma cells may therefore depend on cellular functions associated with differentiation.

Original languageEnglish
Pages (from-to)159-161
Number of pages3
JournalScience
Volume224
Issue number4645
DOIs
Publication statusPublished - Jan 1 1984

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