Cytokines and the central nervous system

Research output: Contribution to journalReview article

255 Citations (Scopus)

Abstract

cytokines and other products of the immune cells can modulate the action, differentiation, and survival of neuronal cells, while the neurotransmitter and neuropeptide release play a pivotal role in influencing the immune response. Cytokines and their receptors are constitutively expressed by and act on neurons in the central nervous system, in both its normal and its pathological state, but cytokine overexpression in the brain is an important factor in the pathogenesis of neurotoxic and neurodegenerative disorders. Accordingly, it can be accepted that the peripheral and central cytokine compartments appear to be integrated, and their effects might synergize or inhibit each other; however, it should always be taken into account that they are spatiotemporally differentially regulated. New concepts are reviewed in the regulation of relations between cytokine balance and neurodegeneration, including intracellular receptor-receptor, cell-cell, and systemic neuroimmune interactions that promote the further elucidation of the complexities and cascade of the possible interactions between cytokines and the central nervous system.

Original languageEnglish
Pages (from-to)329-338
Number of pages10
JournalBrain Research Bulletin
Volume54
Issue number4
DOIs
Publication statusPublished - Mar 1 2001

Keywords

  • Neurodegeneration
  • Neuroimunne interactions
  • Neuroprotection
  • Neurotransmitters
  • Th1/Th2 cytokine balance

ASJC Scopus subject areas

  • Neuroscience(all)

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