Cytokine system as potential target for antipsoriatic therapy

L. Kemény, G. Michel, A. Dobozy, T. Ruzicka

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Cytokines are produced by a variety of cells and have numerous of overlapping activities. There is increasing evidence that cytokines play a crucial role in the pathogenesis of psoriasis and of other dermatologic diseases. This review summarizes current knowledge as to how the altered cytokine network is involved in the accumulation of inflammatory cells in lesional skin, and how the cytokines are involved in epidermal hyperproliferation. The actions of the most important therapeutic compounds, such as corticosteroids, dithranol, cyclosporine, retinoids, vitamin D3 analogues and ultraviolet radiation, on the cytokine system are also discussed. Consideration is given as to how the effects on the production of cytokines and/or cytokine receptors contribute to their therapeutic action.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalExperimental Dermatology
Volume3
Issue number1
DOIs
Publication statusPublished - 1994

Fingerprint

Cytokines
Therapeutics
Anthralin
Cytokine Receptors
Cholecalciferol
Retinoids
Psoriasis
Ultraviolet radiation
Cyclosporine
Skin
Adrenal Cortex Hormones
Cells
Radiation

Keywords

  • cytokines
  • psoriasis
  • therapy

ASJC Scopus subject areas

  • Dermatology

Cite this

Cytokine system as potential target for antipsoriatic therapy. / Kemény, L.; Michel, G.; Dobozy, A.; Ruzicka, T.

In: Experimental Dermatology, Vol. 3, No. 1, 1994, p. 1-8.

Research output: Contribution to journalArticle

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