Cytogenetic studies on mid-trimester abortuses

Peter Ruzicska, E. Czeizel

Research output: Contribution to journalArticle

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Abstract

Cell cultures were set up from the skin, the kidneys, the small intestines, the gonads, and/or the lungs of 103 second trimester spontaneous abortuses. Out of these abortuses 55 gave rise to cell cultures with satisfactory growth. A normal diploid chromosome complement was found in 35 and a chromosome abnormality could be detected in 20 abortuses. X monosomy, autosomal aneuploidy, and structural aberration was observed in 5, 7 and 8 of the 20 abortuses with abnormal karyotypes, respectively. A special characteristic of the results was the high incidence of mosaics among aneuploidies and the frequent occurrence of structural anomalies. Based on these results and on those reported in the literature a pattern of chromosomal-genetic selection occurring during prenatal life was proposed.

Original languageEnglish
Pages (from-to)273-297
Number of pages25
JournalHuman Genetics
Volume10
Issue number4
DOIs
Publication statusPublished - Dec 1970

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Medicine(all)

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