Cytogenetic profile of primary pituitary germinoma

E. Gömöri, D. J. Halbauer, T. Dóczi, E. Balázs, P. Kajtár, L. Pajor

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We present a case of a germinoma in the sellar region of a 10-year-old female patient who presented with a history of polydipsia, polyuria and visual disturbances. The tumor was resected and histologically analyzed. Interphase cytogenetics was performed using chromosome specific (peri)-centromeric DNA probes for all the somatic and X chromosomes on fresh frozen tissues. Fluorescent in situ cell hybridization demonstrated accumulated cytogenetic abnormalities involving significant alterations of chromosome 1, 4, 5/19 and 15. The child was treated postoperatively by radiation and now appears well with only minor neurological deficits. At 3-year follow-up no recurrent tumor mass could be demonstrated.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalJournal of Neuro-Oncology
Volume50
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

Germinoma
Cytogenetics
Polydipsia
Polyuria
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 1
Interphase
DNA Probes
X Chromosome
Fluorescence In Situ Hybridization
Chromosome Aberrations
Neoplasms
Chromosomes
Radiation

Keywords

  • Fluorescent in situ cell hybridization (FISH)
  • Monosomy
  • Primary pituitary germinoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)

Cite this

Cytogenetic profile of primary pituitary germinoma. / Gömöri, E.; Halbauer, D. J.; Dóczi, T.; Balázs, E.; Kajtár, P.; Pajor, L.

In: Journal of Neuro-Oncology, Vol. 50, No. 3, 2000, p. 251-255.

Research output: Contribution to journalArticle

Gömöri, E, Halbauer, DJ, Dóczi, T, Balázs, E, Kajtár, P & Pajor, L 2000, 'Cytogenetic profile of primary pituitary germinoma', Journal of Neuro-Oncology, vol. 50, no. 3, pp. 251-255. https://doi.org/10.1023/A:1006409217130
Gömöri, E. ; Halbauer, D. J. ; Dóczi, T. ; Balázs, E. ; Kajtár, P. ; Pajor, L. / Cytogenetic profile of primary pituitary germinoma. In: Journal of Neuro-Oncology. 2000 ; Vol. 50, No. 3. pp. 251-255.
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