Cytogenetic observations in chronic myeloid leukemia (CML) correlations of the cytogenetic findings with morphological cytochemical features of blast cells in various types of blastic phase

E. Olah, A. Kiss, J. Jako, E. Balogh, K. Rák

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Abstract

49 cases of chronic myeloid leukemia were investigated using cytogenetic methods. 26 patients were studied in chronic phase, 23 during the transformation of the disease. Out of the second group of the patients 9 were myeloid, 5 myelomonocytic, 2 promyelocytic, 2 megakaryoblastic and 5 lymphoid in their morphological and cytochemical appearance. Some correlation could be observed between the clinical, morphological, cytological and cytogenetic findings of different subgroups of the blastic phase in CML. The results demonstrate the divergent clonal evolution of transformed blast cells, and emphasize the importance of chromosome investigations - in addition to the early diagnosis of metamorphosis - in distinguishing the different subgroups of the terminal state of CML.

Original languageEnglish
Pages (from-to)325-332
Number of pages8
JournalNeoplasma
Volume28
Issue number3
Publication statusPublished - Dec 1 1981

ASJC Scopus subject areas

  • Cancer Research

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