Cytogenetic effects of diazepam in peripheral lymphocytes of self-poisoned persons

T. van Bao, Eva Imreh, A. E. Czeizel

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Abstract

The frequencies of chromosomal aberrations and of micronuclei were determined in lymphocyte cultures of 25 patients who attempted suicide with diazepam, 6-12 h, 72 h and 30 days after self-poisoning. These data were compared with those of healthy controls. The frequencies of numerical aberrations showed a significant increase immediately after self-poisoning. However, this effect could not be detected on the 3rd and 30th days after self-poisoning.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalMutation Research/Genetic Toxicology
Volume298
Issue number2
DOIs
Publication statusPublished - Dec 1992

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Keywords

  • Chromosome aberrations
  • Diazepam intoxication
  • Micronuclei

ASJC Scopus subject areas

  • Toxicology
  • Genetics

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