Citogenetikai és hormonális változások fej-nyaki laphámrákos betegekben: Potenciális biomarkerek a funkciómegtartó onkológiai sebészet számára

Translated title of the contribution: Cytogenetic and hormonal changes in head and neck squamous cell cancer patients: potential biomarkers for functional approaches in surgical oncology

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Squamous cell cancer of the head and neck (SCCHN) is the third most common cause of death from cancer among Hungarian males. This cancer is caused in most of the cases by chronic toxic effects of the environment, especially by tobacco smoking and regular alcohol consumption. SCCHNs similar for the first sight, might have different clinical course, mainly because of their different responses to anticancer therapies. In this study, potential biomarkers were examined that were thought to develop as biologic responses to the known environmental toxicities, therefore, their testing is supposed to help answer the most important questions of clinical oncology: understanding tumor development, early detection of cancer and individually tailored therapy planning based on the biological nature of a particular cancer. Elevated rate of spontaneous chromosome aberrations proved to be a reliable marker of the SCCHN phenotype. However, increased mutagen sensitivity by the bleomycin-test, unlike in the US or in Western Europe, was not suitable to detect the individual cancer risk in this country, because of the high mutagen sensitivity of more than half of the healthy Hungarian population examined. In the light of the high cancer incidence and mortality statistics of Hungary, the frequency of elevated mutagen sensitivity even among healthy people is a meaningful finding, and requires further clarification. Our studies on the hormonal status of male SCCHN patients revealed some pathological changes in the sex steroid and pituitary hormone serum levels, which most probably accompanied chronic alcoholic liver disease. The elevated prolactin and decreased total and free testosterone levels predicted poor prognosis of the disease. The importance of the potential relationship between hormones and SCCHN is underscored by our further finding of functioning estrogen and progesterone receptors in SCCHN tissue of our patients. Remenár É. Cytogenetic and hormonal changes in head and neck squamous cell cancer patients: potential biomarkers for functional approaches in surgical oncology. Hungarian Oncology 53:157-164, 2009

Original languageHungarian
Pages (from-to)157-164
Number of pages8
JournalMagyar Onkologia
Volume53
Issue number2
DOIs
Publication statusPublished - 2009

Fingerprint

Squamous Cell Neoplasms
Head and Neck Neoplasms
Cytogenetics
Biomarkers
Head
Mutagens
Neoplasms
Alcoholic Liver Diseases
Pituitary Hormones
Medical Oncology
Hungary
Poisons
Bleomycin
Gonadal Steroid Hormones
Progesterone Receptors
Early Detection of Cancer
Chromosome Aberrations
Alcohol Drinking
Estrogen Receptors
Prolactin

ASJC Scopus subject areas

  • Oncology

Cite this

@article{e5b39c57858a409099bed1182c8e46c1,
title = "Citogenetikai {\'e}s hormon{\'a}lis v{\'a}ltoz{\'a}sok fej-nyaki laph{\'a}mr{\'a}kos betegekben: Potenci{\'a}lis biomarkerek a funkci{\'o}megtart{\'o} onkol{\'o}giai seb{\'e}szet sz{\'a}m{\'a}ra",
abstract = "Squamous cell cancer of the head and neck (SCCHN) is the third most common cause of death from cancer among Hungarian males. This cancer is caused in most of the cases by chronic toxic effects of the environment, especially by tobacco smoking and regular alcohol consumption. SCCHNs similar for the first sight, might have different clinical course, mainly because of their different responses to anticancer therapies. In this study, potential biomarkers were examined that were thought to develop as biologic responses to the known environmental toxicities, therefore, their testing is supposed to help answer the most important questions of clinical oncology: understanding tumor development, early detection of cancer and individually tailored therapy planning based on the biological nature of a particular cancer. Elevated rate of spontaneous chromosome aberrations proved to be a reliable marker of the SCCHN phenotype. However, increased mutagen sensitivity by the bleomycin-test, unlike in the US or in Western Europe, was not suitable to detect the individual cancer risk in this country, because of the high mutagen sensitivity of more than half of the healthy Hungarian population examined. In the light of the high cancer incidence and mortality statistics of Hungary, the frequency of elevated mutagen sensitivity even among healthy people is a meaningful finding, and requires further clarification. Our studies on the hormonal status of male SCCHN patients revealed some pathological changes in the sex steroid and pituitary hormone serum levels, which most probably accompanied chronic alcoholic liver disease. The elevated prolactin and decreased total and free testosterone levels predicted poor prognosis of the disease. The importance of the potential relationship between hormones and SCCHN is underscored by our further finding of functioning estrogen and progesterone receptors in SCCHN tissue of our patients. Remen{\'a}r {\'E}. Cytogenetic and hormonal changes in head and neck squamous cell cancer patients: potential biomarkers for functional approaches in surgical oncology. Hungarian Oncology 53:157-164, 2009",
keywords = "Biomarkers, Chromosome aberrations, Epidemiology, Head and neck cancer, Mutagen sensitivity, Pituitary hormones, Prognosis, Sex steroid hormones",
author = "E. Remen{\'a}r",
year = "2009",
doi = "10.1556/MOnkol.53.2009.2.8",
language = "Hungarian",
volume = "53",
pages = "157--164",
journal = "Magyar Onkologia",
issn = "0025-0244",
publisher = "Akademiai Kiado",
number = "2",

}

TY - JOUR

T1 - Citogenetikai és hormonális változások fej-nyaki laphámrákos betegekben

T2 - Potenciális biomarkerek a funkciómegtartó onkológiai sebészet számára

AU - Remenár, E.

PY - 2009

Y1 - 2009

N2 - Squamous cell cancer of the head and neck (SCCHN) is the third most common cause of death from cancer among Hungarian males. This cancer is caused in most of the cases by chronic toxic effects of the environment, especially by tobacco smoking and regular alcohol consumption. SCCHNs similar for the first sight, might have different clinical course, mainly because of their different responses to anticancer therapies. In this study, potential biomarkers were examined that were thought to develop as biologic responses to the known environmental toxicities, therefore, their testing is supposed to help answer the most important questions of clinical oncology: understanding tumor development, early detection of cancer and individually tailored therapy planning based on the biological nature of a particular cancer. Elevated rate of spontaneous chromosome aberrations proved to be a reliable marker of the SCCHN phenotype. However, increased mutagen sensitivity by the bleomycin-test, unlike in the US or in Western Europe, was not suitable to detect the individual cancer risk in this country, because of the high mutagen sensitivity of more than half of the healthy Hungarian population examined. In the light of the high cancer incidence and mortality statistics of Hungary, the frequency of elevated mutagen sensitivity even among healthy people is a meaningful finding, and requires further clarification. Our studies on the hormonal status of male SCCHN patients revealed some pathological changes in the sex steroid and pituitary hormone serum levels, which most probably accompanied chronic alcoholic liver disease. The elevated prolactin and decreased total and free testosterone levels predicted poor prognosis of the disease. The importance of the potential relationship between hormones and SCCHN is underscored by our further finding of functioning estrogen and progesterone receptors in SCCHN tissue of our patients. Remenár É. Cytogenetic and hormonal changes in head and neck squamous cell cancer patients: potential biomarkers for functional approaches in surgical oncology. Hungarian Oncology 53:157-164, 2009

AB - Squamous cell cancer of the head and neck (SCCHN) is the third most common cause of death from cancer among Hungarian males. This cancer is caused in most of the cases by chronic toxic effects of the environment, especially by tobacco smoking and regular alcohol consumption. SCCHNs similar for the first sight, might have different clinical course, mainly because of their different responses to anticancer therapies. In this study, potential biomarkers were examined that were thought to develop as biologic responses to the known environmental toxicities, therefore, their testing is supposed to help answer the most important questions of clinical oncology: understanding tumor development, early detection of cancer and individually tailored therapy planning based on the biological nature of a particular cancer. Elevated rate of spontaneous chromosome aberrations proved to be a reliable marker of the SCCHN phenotype. However, increased mutagen sensitivity by the bleomycin-test, unlike in the US or in Western Europe, was not suitable to detect the individual cancer risk in this country, because of the high mutagen sensitivity of more than half of the healthy Hungarian population examined. In the light of the high cancer incidence and mortality statistics of Hungary, the frequency of elevated mutagen sensitivity even among healthy people is a meaningful finding, and requires further clarification. Our studies on the hormonal status of male SCCHN patients revealed some pathological changes in the sex steroid and pituitary hormone serum levels, which most probably accompanied chronic alcoholic liver disease. The elevated prolactin and decreased total and free testosterone levels predicted poor prognosis of the disease. The importance of the potential relationship between hormones and SCCHN is underscored by our further finding of functioning estrogen and progesterone receptors in SCCHN tissue of our patients. Remenár É. Cytogenetic and hormonal changes in head and neck squamous cell cancer patients: potential biomarkers for functional approaches in surgical oncology. Hungarian Oncology 53:157-164, 2009

KW - Biomarkers

KW - Chromosome aberrations

KW - Epidemiology

KW - Head and neck cancer

KW - Mutagen sensitivity

KW - Pituitary hormones

KW - Prognosis

KW - Sex steroid hormones

UR - http://www.scopus.com/inward/record.url?scp=69849084875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69849084875&partnerID=8YFLogxK

U2 - 10.1556/MOnkol.53.2009.2.8

DO - 10.1556/MOnkol.53.2009.2.8

M3 - Article

C2 - 19581182

AN - SCOPUS:69849084875

VL - 53

SP - 157

EP - 164

JO - Magyar Onkologia

JF - Magyar Onkologia

SN - 0025-0244

IS - 2

ER -