Cytogenetic and embryotoxic effects of bromophos and demethylbromophos

M. Nehéz, E. Huszta, É Mazzag, H. Scheufler, G. W. Fischer, I. Dési

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The organophosphorus pesticide bromophos and the tetramethylammonium and sodium salts of demethylbromophos were tested for cytogenetic and embryotoxic activity on mice of different strains. Single intraperitoneal (ip) doses of 183.0 mg/kg (0.5 mmol/kg) and 73.2 mg/kg (0.2 mmol/kg) bromophos caused a significant enhancement in the percentage of chromosome aberrations in bone marrow cells of CFLP mice; similar effects were produced by a single dose of 0.2 mmol/kg demethylbromophos tetramethylammonium salt and demethylbromophos sodium salt trihydrate, respectively, indicating that the cytogenetic activity of bromophos is not connected with its alkylating properties. After repeated ip or oral administration to pregnant mice of strains AB Jena/Halle and DBA, none of the tested compounds showed a marked influence on the total implantation losses, although in some cases the postimplantation losses were significantly increased.

Original languageEnglish
Pages (from-to)416-421
Number of pages6
JournalRegulatory Toxicology and Pharmacology
Volume6
Issue number4
DOIs
Publication statusPublished - 1986

Fingerprint

bromophos
Cytogenetics
Salts
Sodium
Chromosomes
Aberrations
Pesticides
Chromosome Aberrations
Bone Marrow Cells
Oral Administration
Bone
Cells

ASJC Scopus subject areas

  • Toxicology

Cite this

Cytogenetic and embryotoxic effects of bromophos and demethylbromophos. / Nehéz, M.; Huszta, E.; Mazzag, É; Scheufler, H.; Fischer, G. W.; Dési, I.

In: Regulatory Toxicology and Pharmacology, Vol. 6, No. 4, 1986, p. 416-421.

Research output: Contribution to journalArticle

Nehéz, M. ; Huszta, E. ; Mazzag, É ; Scheufler, H. ; Fischer, G. W. ; Dési, I. / Cytogenetic and embryotoxic effects of bromophos and demethylbromophos. In: Regulatory Toxicology and Pharmacology. 1986 ; Vol. 6, No. 4. pp. 416-421.
@article{b237b51c0acd45f28bfcf0407a227782,
title = "Cytogenetic and embryotoxic effects of bromophos and demethylbromophos",
abstract = "The organophosphorus pesticide bromophos and the tetramethylammonium and sodium salts of demethylbromophos were tested for cytogenetic and embryotoxic activity on mice of different strains. Single intraperitoneal (ip) doses of 183.0 mg/kg (0.5 mmol/kg) and 73.2 mg/kg (0.2 mmol/kg) bromophos caused a significant enhancement in the percentage of chromosome aberrations in bone marrow cells of CFLP mice; similar effects were produced by a single dose of 0.2 mmol/kg demethylbromophos tetramethylammonium salt and demethylbromophos sodium salt trihydrate, respectively, indicating that the cytogenetic activity of bromophos is not connected with its alkylating properties. After repeated ip or oral administration to pregnant mice of strains AB Jena/Halle and DBA, none of the tested compounds showed a marked influence on the total implantation losses, although in some cases the postimplantation losses were significantly increased.",
author = "M. Neh{\'e}z and E. Huszta and {\'E} Mazzag and H. Scheufler and Fischer, {G. W.} and I. D{\'e}si",
year = "1986",
doi = "10.1016/0273-2300(86)90009-7",
language = "English",
volume = "6",
pages = "416--421",
journal = "Regulatory Toxicology and Pharmacology",
issn = "0273-2300",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - Cytogenetic and embryotoxic effects of bromophos and demethylbromophos

AU - Nehéz, M.

AU - Huszta, E.

AU - Mazzag, É

AU - Scheufler, H.

AU - Fischer, G. W.

AU - Dési, I.

PY - 1986

Y1 - 1986

N2 - The organophosphorus pesticide bromophos and the tetramethylammonium and sodium salts of demethylbromophos were tested for cytogenetic and embryotoxic activity on mice of different strains. Single intraperitoneal (ip) doses of 183.0 mg/kg (0.5 mmol/kg) and 73.2 mg/kg (0.2 mmol/kg) bromophos caused a significant enhancement in the percentage of chromosome aberrations in bone marrow cells of CFLP mice; similar effects were produced by a single dose of 0.2 mmol/kg demethylbromophos tetramethylammonium salt and demethylbromophos sodium salt trihydrate, respectively, indicating that the cytogenetic activity of bromophos is not connected with its alkylating properties. After repeated ip or oral administration to pregnant mice of strains AB Jena/Halle and DBA, none of the tested compounds showed a marked influence on the total implantation losses, although in some cases the postimplantation losses were significantly increased.

AB - The organophosphorus pesticide bromophos and the tetramethylammonium and sodium salts of demethylbromophos were tested for cytogenetic and embryotoxic activity on mice of different strains. Single intraperitoneal (ip) doses of 183.0 mg/kg (0.5 mmol/kg) and 73.2 mg/kg (0.2 mmol/kg) bromophos caused a significant enhancement in the percentage of chromosome aberrations in bone marrow cells of CFLP mice; similar effects were produced by a single dose of 0.2 mmol/kg demethylbromophos tetramethylammonium salt and demethylbromophos sodium salt trihydrate, respectively, indicating that the cytogenetic activity of bromophos is not connected with its alkylating properties. After repeated ip or oral administration to pregnant mice of strains AB Jena/Halle and DBA, none of the tested compounds showed a marked influence on the total implantation losses, although in some cases the postimplantation losses were significantly increased.

UR - http://www.scopus.com/inward/record.url?scp=0023003766&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023003766&partnerID=8YFLogxK

U2 - 10.1016/0273-2300(86)90009-7

DO - 10.1016/0273-2300(86)90009-7

M3 - Article

C2 - 3809618

AN - SCOPUS:0023003766

VL - 6

SP - 416

EP - 421

JO - Regulatory Toxicology and Pharmacology

JF - Regulatory Toxicology and Pharmacology

SN - 0273-2300

IS - 4

ER -